Evidence map›Paper›PMID 38465513›Full record

ArticleJournal of cell science2024

The Drosophila neuroblast polarity cycle at a glance.

Rhiannon R Penkert, Bryce LaFoya, Lucille Moholt-Siebert, Elizabeth Vargas, Sarah E Welch, Kenneth E Prehoda

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cell science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Altering cell size asymmetry inbioRxiv : the preprint server for biology · 2025
    Article
  4. A PDZ-kinase allosteric relay mediates Par complex regulator exchange.bioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rhiannon R PenkertDepartment of Chemistry and Biochemistry, Institute of Molecular Biology, University of Oregon, 1318 Franklin Blvd, Eugene, OR 97403, USA.
Bryce LaFoyaDepartment of Chemistry and Biochemistry, Institute of Molecular Biology, University of Oregon, 1318 Franklin Blvd, Eugene, OR 97403, USA.
Lucille Moholt-SiebertDepartment of Chemistry and Biochemistry, Institute of Molecular Biology, University of Oregon, 1318 Franklin Blvd, Eugene, OR 97403, USA.
Elizabeth VargasDepartment of Chemistry and Biochemistry, Institute of Molecular Biology, University of Oregon, 1318 Franklin Blvd, Eugene, OR 97403, USA.
Sarah E WelchDepartment of Chemistry and Biochemistry, Institute of Molecular Biology, University of Oregon, 1318 Franklin Blvd, Eugene, OR 97403, USA.
Kenneth E PrehodaDepartment of Chemistry and Biochemistry, Institute of Molecular Biology, University of Oregon, 1318 Franklin Blvd, Eugene, OR 97403, USA.ORCID 0000-0003-4214-6158
University of Oregon · US

Funding

DEVELOPMENTAL BIOLOGY TRAINING PROGRAMT32HD007348 · NICHD · UNIVERSITY OF OREGON · PI Chris Q Doe, KRYN STANKUNAS · 1989 to 2026
$6.8M
Molecular mechanisms that regulate polarity and spindle orientation in animals - admin supplement to purchase Zeiss Airyscan detector upgradeR35GM127092 · NIGMS · UNIVERSITY OF OREGON · PI Kenneth E Prehoda · 2018 to 2026
$3.6M
Proliferative asymmetry in the neural stem cell lineage established by asymmetric cell divisionK99GM147601 · NIGMS · UNIVERSITY OF OREGON · PI LAFOYA, BRYCE · 2023 to 2024
$250k
Elucidating the mechanism of cell type specific regulation of the Par complexF31GM149175 · NIGMS · UNIVERSITY OF OREGON · PI VARGAS, ELIZABETH · 2023 to 2023
$39k
NICHD NIH HHS T32 HD007348NIGMS NIH HHS F31 GM149175NIGMS NIH HHS K99 GM147601NIGMS NIH HHS R35 GM127092NIH HHS GM127092
6 · The paper itself

Abstract

Drosophila neural stem cells, or neuroblasts, rapidly proliferate during embryonic and larval development to populate the central nervous system. Neuroblasts divide asymmetrically to create cellular diversity, with each division producing one sibling cell that retains the neuroblast fate and another that differentiates into glia or neurons. This asymmetric outcome is mediated by the transient polarization of numerous factors to the cell cortex during mitosis. The powerful genetics and outstanding imaging tractability of the neuroblast make it an excellent model system for studying the mechanisms of cell polarity. This Cell Science at a Glance article and the accompanying poster explore the phases of the neuroblast polarity cycle and the regulatory circuits that control them. We discuss the key features of the cycle - the targeted recruitment of proteins to specific regions of the plasma membrane and multiple phases of highly dynamic actomyosin-dependent cortical flows that pattern both protein distribution and membrane structure.

Indexed as

Drosophila ProteinsNeural Stem CellsAnimalsCell Cycle ProteinsCell PolarityDrosophilaMitosisNeuronsCell Cycle ProteinsDrosophila ProteinsAsymmetric cell divisionCell cycleCell polarityDrosophilaNeuroblastStem cell

Identifiers

PMID38465513
PMCPMC10984279
OpenAlexW4392655257

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.