Evidence map›Paper›PMID 38465625›Full record

ArticleHypertension (Dallas, Tex. : 1979)2024

Potassium-Switch Signaling Pathway Dictates Acute Blood Pressure Response to Dietary Potassium.

Paul A Welling, Robert Little, Lama Al-Qusairi, Eric Delpire, David H Ellison, Robert A Fenton, P Richard Grimm

Open access · goldAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Potassium and the kidney.Nature reviews. Nephrology · 2026
    Review
  7. How Does Dietary Potassium Influence BP?Journal of the American Society of Nephrology : JASN · 2026
    Review
  8. New evidence linking lifestyle factors to blood pressure: Focus on 2024 findings.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Review
  9. Review
  10. Nutrients · 2026
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Macrophage SPAK deletion limits a low potassium-induced kidney inflammatory program.American journal of physiology. Renal physiology · 2024
    Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Paul A WellingDepartment of Medicine, Division of Nephrology (P.A.W., L.A.-Q., P.R.G.), Johns Hopkins University School of Medicine, Baltimore, MD.
Robert LittleDepartment of Biomedicine, University of Aarhus, Denmark (R.L., R.A.F.).
Lama Al-QusairiDepartment of Medicine, Division of Nephrology (P.A.W., L.A.-Q., P.R.G.), Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0002-2956-2811
Eric DelpireDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN (E.D.).ORCID 0000-0002-3702-1599
David H EllisonDepartment of Medicine, Division of Nephrology, Oregon Health Science Center, Portland (D.H.E.).ORCID 0000-0003-2915-265X
Robert A FentonDepartment of Biomedicine, University of Aarhus, Denmark (R.L., R.A.F.).ORCID 0000-0003-1623-199X
P Richard GrimmDepartment of Medicine, Division of Nephrology (P.A.W., L.A.-Q., P.R.G.), Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0002-9368-0601
Johns Hopkins University · USAarhus University · DKTwitter (United States) · USVanderbilt University Medical Center · US

Funding

WNK-SPAK signaling in the Distal NephronR01DK093501 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire, Paul A Welling · 2012 to 2026
$12.1M
WNK Kinase Regulation of Thiazide-sensitive NaCl TransportR01DK051496 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI David Hoadley Ellison, CHAO-LING YANG · 1998 to 2026
$8.4M
Molecular of ROMK Channel FunctionR01DK054231 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI Paul A Welling · 1998 to 2026
$7.7M
OXGR1 in Renal Intercalated Cells, Salt Transport and Diuretic EfficacyR01DK110375 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire, SUSAN MARIE WALL · 2017 to 2026
$6.7M
Role of Kir4.1 in regulating NCC and ROMK in DCTR01DK133220 · NIDDK · NEW YORK MEDICAL COLLEGE · PI ELLISON, DAVID HOADLEY, WANG, WENHUI · 2022 to 2025
$2.6M
Multigene Kinase Network, Kidney Transport and Salt in Essential HypertensionRC1DK086817 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI WELLING, PAUL A · 2009 to 2010
$1000k
NIDDK NIH HHS R01 DK051496NIDDK NIH HHS R01 DK054231NIDDK NIH HHS R01 DK093501NIDDK NIH HHS R01 DK110375NIDDK NIH HHS R01 DK133220NIDDK NIH HHS RC1 DK086817
6 · The paper itself

Abstract

backgroundPotassium (K

methodsTo test the hypothesis that small, physiological changes in plasma K

resultsAs P

conclusionsLow K

Indexed as

PotassiumProtein Serine-Threonine KinasesAlanineAnimalsBlood PressureHydrochlorothiazideKidney Tubules, DistalMicePhosphorylationPotassium, DietaryProlineSignal TransductionSodiumSodium ChlorideSolute Carrier Family 12, Member 3AlanineHydrochlorothiazidePotassiumPotassium, DietaryProlineProtein Serine-Threonine KinasesSodiumSodium ChlorideSolute Carrier Family 12, Member 3hydrochlorothiazidehypertensionphosphorylationpotassiumsodium chloride

Identifiers

PMID38465625
PMCPMC11023808
OpenAlexW4392648925

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.