Evidence map›Paper›PMID 38465747›Full record

ArticleeLife2024

A binding site for phosphoinositides described by multiscale simulations explains their modulation of voltage-gated sodium channels.

Yiechang Lin, Elaine Tao, James P Champion, Ben Corry

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. PIPbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Nonsubstrate PI(4,5)PProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yiechang Lin *Research School of Biology, Australian National University, Canberra, Australia.ORCID https://orcid.org/0000-0001-9836-132X
Elaine Tao *Research School of Biology, Australian National University, Canberra, Australia.ORCID https://orcid.org/0000-0003-0332-1646
James P ChampionResearch School of Biology, Australian National University, Canberra, Australia.
Ben CorryResearch School of Biology, Australian National University, Canberra, Australia.ORCID https://orcid.org/0000-0002-6324-442X
Australian National University · AU

Funding

Australian Government Research Training Program ScholarshipNational Computational Infrastructure NCI HPC-AI Talent Program Scholarship
6 · The paper itself

Abstract

Voltage-gated sodium channels (Naᵥ) are membrane proteins which open to facilitate the inward flux of sodium ions into excitable cells. In response to stimuli, Naᵥ channels transition from the resting, closed state to an open, conductive state, before rapidly inactivating. Dysregulation of this functional cycle due to mutations causes diseases including epilepsy, pain conditions, and cardiac disorders, making Naᵥ channels a significant pharmacological target. Phosphoinositides are important lipid cofactors for ion channel function. The phosphoinositide PI(4,5)P

Indexed as

Ion Channel GatingVoltage-Gated Sodium ChannelsBinding SitesIon ChannelsProtein DomainsIon ChannelsVoltage-Gated Sodium Channelsinactivationion channellipid-protein interactionmolecular biophysicsmolecular dynamicsnonephosphoinositidesodium channelstructural biology

Identifiers

PMID38465747
PMCPMC10928511
OpenAlexW4387378974

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.