Evidence map›Paper›PMID 38466127›Full record

ArticleMicrobiology spectrum2024

Potent small molecule inhibitors against the 3C protease of foot-and-mouth disease virus.

Yunjeong Kim, Emma Pool, Eunji Kim, Chamandi S Dampalla, Harry Nhat Nguyen, David K Johnson, Scott Lovell, William C Groutas, Kyeong-Ok Chang

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.3field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yunjeong KimDepartment of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA.ORCID 0000-0002-2977-4400
Emma PoolDepartment of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA.
Eunji KimDepartment of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA.
Chamandi S DampallaDepartment of Chemistry, Wichita State University, Wichita, Kansas, USA.
Harry Nhat NguyenDepartment of Chemistry, Wichita State University, Wichita, Kansas, USA.
David K JohnsonComputational Chemical Biology Core, The University of Kansas, Lawrence, Kansas, USA.
Scott LovellProtein Structure and X-ray Crystallography Laboratory, The University of Kansas, Lawrence, Kansas, USA.
William C GroutasDepartment of Chemistry, Wichita State University, Wichita, Kansas, USA.
Kyeong-Ok ChangDepartment of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA.ORCID 0000-0002-4435-3751
Kansas State University · USWichita State University · USUniversity of Kansas · US

Funding

Small Molecule Protease Inhibitors against MERS-CoV and Coronaviruses of Pandemic PotentialR01AI130092 · NIAID · KANSAS STATE UNIVERSITY · PI Kyeong-Ok Chang, William Constantine Groutas · 2018 to 2026
$5.9M
Small Molecule Inhibitors Against 3C-Like Protease of SARS-CoV-2R01AI161085 · NIAID · KANSAS STATE UNIVERSITY · PI Kyeong-Ok Chang, William Constantine Groutas · 2021 to 2026
$3.7M
NIAID NIH HHS R01 AI130092NIAID NIH HHS R01 AI161085
6 · The paper itself

Abstract

Foot-and-mouth disease (FMD) is one of the most devastating diseases of livestock which can cause significant economic losses, especially when introduced to FMD-free countries. FMD virus (FMDV) belongs to the family

Indexed as

Foot-and-Mouth DiseaseFoot-and-Mouth Disease Virus3C Viral ProteasesAnimalsAntiviral AgentsEndopeptidasesPeptide HydrolasesSerogroup3C Viral ProteasesAntiviral AgentsEndopeptidasesPeptide Hydrolases3C proteaseantiviralfood-and-mouth diseaseprotease inhibitorstructure-activity relationships

Identifiers

PMID38466127
PMCPMC10986521
OpenAlexW4392643984

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.