ArticleNature communications2024
The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 7 citations in OpenAlex.
- Familial, neuropathological and cellular analysis identify ARPP21 as a major amyotrophic lateral sclerosis associated gene in French cohorts.Acta neuropathologica · 2026Article
- Interpretable spatial multi-omics data integration and dimensionality reduction with SpaMV.Nature communications · 2026Article
- RNA-binding proteins and ribonucleoproteins as determinants of immunity.Nature reviews. Immunology · 2026Review
- Microenvironment-aware spatial modeling for accurate inference of cell identity.Nucleic acids research · 2026Article
- Physiological upregulation of RAG1 expression compromises the survival of CD4Frontiers in immunology · 2026Article
- Preselection CD4bioRxiv : the preprint server for biology · 2025Article
- Interpretable spatial multi-omics data integration and dimension reduction with SpaMV.Research square · 2025Article
- A single-cell V(D)J sequencing dataset of peripheral blood cells in multibacillary leprosy.Scientific data · 2025Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
25 authors at 12 institutions in 4 countries.
Meng Xu *Research Unit Molecular Immune Regulation, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, Munich, Germany.
Taku Ito-Kureha *Institute for Immunology, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität in Munich, Planegg-Martinsried, Germany.ORCID 0000-0002-6239-9227
Hyun-Seo KangInstitute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0003-4029-5096
Aleksandar ChernevMax Planck Institute for Multidisciplinary Sciences, Bioanalytical Mass Spectrometry, Göttingen, Germany.
Timsse RajInstitute for Immunology, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität in Munich, Planegg-Martinsried, Germany.ORCID 0000-0002-5065-8092
Kai P HoefigResearch Unit Molecular Immune Regulation, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, Munich, Germany.
Christine HohnInstitute for Immunology, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität in Munich, Planegg-Martinsried, Germany.
Florian GiesertInstitute of Developmental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0001-6825-8858
Yinhu WangDepartment of Pathology, New York University, Grossman School of Medicine, New York, NY, USA.ORCID 0000-0002-3637-8852
Wenliang PanDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Natalia ZiętaraInstitute for Immunology, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität in Munich, Planegg-Martinsried, Germany.
Tobias StraubInstitute for Molecular Biology, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität in Munich, Planegg-Martinsried, Germany.ORCID 0000-0002-0547-0453
Regina FeederleMonoclonal Antibody Core Facility, German Research Center for Environmental Health, Neuherberg, Germany.ORCID 0000-0002-3981-367X
Carolin DanielResearch Unit Type 1 Diabetes Immunology, Helmholtz Diabetes Center at Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0003-4698-7069
Barbara AdlerMax von Pettenkofer Institute, Faculty of Medicine, Ludwig-Maximilians-Universität in Munich, Munich, Germany.
Julian KönigInstitute of Molecular Biology (IMB), Mainz, Germany.ORCID 0000-0002-9398-5421
Stefan FeskeDepartment of Pathology, New York University, Grossman School of Medicine, New York, NY, USA.
George C TsokosDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-9589-2360
Wolfgang WurstInstitute of Developmental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0003-4422-7410
Henning UrlaubMax Planck Institute for Multidisciplinary Sciences, Bioanalytical Mass Spectrometry, Göttingen, Germany.ORCID 0000-0003-1837-5233
Michael SattlerInstitute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0002-1594-0527
Jan KisielowInstitute for Molecular Health Sciences, ETH Zürich, Zürich, Switzerland. jk@repertoire.com.ORCID 0000-0002-4482-5202
F Gregory WulczynInstitute for Integrative Neuroanatomie, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. gregory.wulczyn@charite.de.ORCID 0000-0001-9850-2444
Marcin ŁyszkiewiczResearch Unit Molecular Immune Regulation, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, Munich, Germany. marcin.lyszkiewicz@uni-ulm.de.
Vigo HeissmeyerResearch Unit Molecular Immune Regulation, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, Munich, Germany. vigo.heissmeyer@med.uni-muenchen.de.ORCID 0000-0002-2263-8545
Helmholtz Zentrum München · DELudwig-Maximilians-Universität München · DEBeth Israel Deaconess Medical Center · USNew York University · USBoehringer Ingelheim (Germany) · DEGerman Center for Neurodegenerative Diseases · DEHumboldt-Universität zu Berlin · DEInstitute for Biomedical Engineering · CHInstitute of Molecular Biology · DEMax Planck Institute for Multidisciplinary SciencesUniversitätsmedizin Göttingen · DEUniversität Ulm · DE
Funding
Phosphatases in Systemic AutoimmunityR01AI136924 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI TSOKOS, GEORGE C · 2018 to 2022
$2.2MNIAID NIH HHS R01 AI136924
Abstract
The regulation of thymocyte development by RNA-binding proteins (RBPs) is largely unexplored. We identify 642 RBPs in the thymus and focus on Arpp21, which shows selective and dynamic expression in early thymocytes. Arpp21 is downregulated in response to T cell receptor (TCR) and Ca
Indexed as
Receptors, Antigen, T-CellThymocytesAnimalsCell DifferentiationHomeodomain ProteinsMicePhosphoproteinsRNA-Binding ProteinsRNA, MessengerThymus Glandcyclic AMP-regulated phosphoprotein ARPP-21Homeodomain ProteinsPhosphoproteinsRAG-1 proteinReceptors, Antigen, T-CellRNA-Binding ProteinsRNA, Messenger
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.