ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024
Fluorescent Solvatochromic Probes for Long-Term Imaging of Lipid Order in Living Cells.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- The multifaceted significance of phosphoinositides in endocytic trafficking.FEBS letters · 2026Review
- Unveiling the fluorescence lifetime changes of a solvatochromic aurone probe dye upon wetting in an emissive polymer brush matrix by deconvolution of TCSPC data.The European physical journal. E, Soft matter · 2026Article
- Bright Solvatochromic Fluorophores With Dual Emission Enabled by a Donor-Engineering Strategy.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Fluorescence Analysis of Local Microenvironments in Polymer Films Using Solvatochromic Dyes.Sensors (Basel, Switzerland) · 2026Article
- Article
- Trifluoroacetyl-Substituted D-π-A Fluorophores: Design Strategies for Strong Solvatochromism and Giga Stokes Shifts.Chemistry, an Asian journal · 2025Article
- Development of 2,1,3-Benzothiadiazole-Based Room-Temperature Fluorescent Nematic Liquid Crystals.Molecules (Basel, Switzerland) · 2025Article
- D-π-A Fluorophores with Strong Solvatochromism for Single-Molecule Ratiometric Thermometers.Journal of the American Chemical Society · 2025Article
- Fluorescent Solvatochromic Probes for Long-Term Imaging of Lipid Order in Living Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
High-resolution spatio-temporal monitoring of the cell membrane lipid order provides visual insights into the complex and sophisticated systems that control cellular physiological functions. Solvatochromic fluorescent probes are highly promising noninvasive visualization tools for identifying the ordering of the microenvironment of plasma membrane microdomains. However, conventional probes, although capable of structural analysis, lack the necessary long-term photostability required for live imaging at the cellular level. Here, an ultra-high-light-resistant solvatochromic fluorescence probe, 2-N,N-diethylamino-7-(4-methoxycarbonylphenyl)-9,9-dimethylfluorene (FπCM) is reported, which enables live lipid order imaging of cell division. This probe and its derivatives exhibit sufficient fluorescence wavelengths, brightness, polarity responsiveness, low phototoxicity, and remarkable photostability under physiological conditions compared to conventional solvatochromic probes. Therefore, these probes have the potential to overcome the limitations of fluorescence microscopy, particularly those associated with photobleaching. FπCM probes can serve as valuable tools for elucidating mechanisms of cellular processes at the bio-membrane level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.