Evidence map›Paper›PMID 38469320›Full record

ArticleCurrent research in toxicology2024

In vitro-in silico study on the influence of dose, fraction bioactivated and endpoint used on the relative potency value of pyrrolizidine alkaloid N-oxides compared to parent pyrrolizidine alkaloids.

Yasser Alhejji, Frances Widjaja, Shenghan Tian, Thomas Hoekstra, Sebastiaan Wesseling, Ivonne M C M Rietjens

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Yasser AlhejjiDivision of Toxicology, Wageningen University, PO Box 8000, 6700 EA Wageningen, the Netherlands.
Frances WidjajaDivision of Toxicology, Wageningen University, PO Box 8000, 6700 EA Wageningen, the Netherlands.
Shenghan TianDivision of Toxicology, Wageningen University, PO Box 8000, 6700 EA Wageningen, the Netherlands.
Thomas HoekstraDivision of Toxicology, Wageningen University, PO Box 8000, 6700 EA Wageningen, the Netherlands.
Sebastiaan WesselingDivision of Toxicology, Wageningen University, PO Box 8000, 6700 EA Wageningen, the Netherlands.
Ivonne M C M RietjensDivision of Toxicology, Wageningen University, PO Box 8000, 6700 EA Wageningen, the Netherlands.
Wageningen University & Research · NLQassim University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyrrolizidine alkaloids (PAs) and their N-oxides (PA-N-oxides) are phytotoxins found in food, feed and the environment. Yet, limited data exist from which the relative potency of a PA-N-oxide relative to its corresponding PA (REP

Indexed as

7-GS-DHPPhysiologically based kinetic modelingPyrrole-DNA adductsPyrrole-protein adductsPyrrolizidine alkaloidPyrrolizidine alkaloid N-oxideRatRelative potency value

Identifiers

PMID38469320
PMCPMC10926302
OpenAlexW4392387953

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.