Evidence mapPaperPMID 38470236Full record

ReviewRadiology2024

Interpretation, Reporting, and Clinical Applications of Liver MR Elastography.

Guilherme Moura Cunha, Boyan Fan, Patrick J Navin, Damien Olivié, Sudhakar K Venkatesh, Richard L Ehman, Claude B Sirlin, An Tang

Open access · greenAbstract readReview
In one paragraph

Review in Radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
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  16. Article
  17. [Advances and challenges in new technologies for imaging evaluation of liver fibrosis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
    Review
  18. Accelerated Abdominal MRI: A Review of Current Methods and Applications.Journal of magnetic resonance imaging : JMRI · 2025
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Guilherme Moura CunhaFrom the Department of Radiology, University of Washington, Seattle, Wash (G.M.C.); Department of Radiology, Université Laval, Québec, Québec, Canada (B.F.); Department of Radiology, Mayo Clinic, Rochester, Minn (P.J.N., S.K.V., R.L.E.); Department of Radiology, Centre Hospitalier de l'Université de Montréal, 1058 Rue Saint-Denis, Montréal, QC, Canada H2X 3J4 (D.O., A.T.); and Department of Radiology, University of California San Diego, San Diego, Calif (C.B.S.).ORCID 0000-0001-6403-5155
Boyan FanFrom the Department of Radiology, University of Washington, Seattle, Wash (G.M.C.); Department of Radiology, Université Laval, Québec, Québec, Canada (B.F.); Department of Radiology, Mayo Clinic, Rochester, Minn (P.J.N., S.K.V., R.L.E.); Department of Radiology, Centre Hospitalier de l'Université de Montréal, 1058 Rue Saint-Denis, Montréal, QC, Canada H2X 3J4 (D.O., A.T.); and Department of Radiology, University of California San Diego, San Diego, Calif (C.B.S.).ORCID 0009-0001-6646-4735
Patrick J NavinFrom the Department of Radiology, University of Washington, Seattle, Wash (G.M.C.); Department of Radiology, Université Laval, Québec, Québec, Canada (B.F.); Department of Radiology, Mayo Clinic, Rochester, Minn (P.J.N., S.K.V., R.L.E.); Department of Radiology, Centre Hospitalier de l'Université de Montréal, 1058 Rue Saint-Denis, Montréal, QC, Canada H2X 3J4 (D.O., A.T.); and Department of Radiology, University of California San Diego, San Diego, Calif (C.B.S.).ORCID 0000-0002-8095-9283
Damien OliviéFrom the Department of Radiology, University of Washington, Seattle, Wash (G.M.C.); Department of Radiology, Université Laval, Québec, Québec, Canada (B.F.); Department of Radiology, Mayo Clinic, Rochester, Minn (P.J.N., S.K.V., R.L.E.); Department of Radiology, Centre Hospitalier de l'Université de Montréal, 1058 Rue Saint-Denis, Montréal, QC, Canada H2X 3J4 (D.O., A.T.); and Department of Radiology, University of California San Diego, San Diego, Calif (C.B.S.).
Sudhakar K VenkateshFrom the Department of Radiology, University of Washington, Seattle, Wash (G.M.C.); Department of Radiology, Université Laval, Québec, Québec, Canada (B.F.); Department of Radiology, Mayo Clinic, Rochester, Minn (P.J.N., S.K.V., R.L.E.); Department of Radiology, Centre Hospitalier de l'Université de Montréal, 1058 Rue Saint-Denis, Montréal, QC, Canada H2X 3J4 (D.O., A.T.); and Department of Radiology, University of California San Diego, San Diego, Calif (C.B.S.).ORCID 0000-0002-7514-1030
Richard L EhmanFrom the Department of Radiology, University of Washington, Seattle, Wash (G.M.C.); Department of Radiology, Université Laval, Québec, Québec, Canada (B.F.); Department of Radiology, Mayo Clinic, Rochester, Minn (P.J.N., S.K.V., R.L.E.); Department of Radiology, Centre Hospitalier de l'Université de Montréal, 1058 Rue Saint-Denis, Montréal, QC, Canada H2X 3J4 (D.O., A.T.); and Department of Radiology, University of California San Diego, San Diego, Calif (C.B.S.).ORCID 0000-0001-7041-5074
Claude B SirlinFrom the Department of Radiology, University of Washington, Seattle, Wash (G.M.C.); Department of Radiology, Université Laval, Québec, Québec, Canada (B.F.); Department of Radiology, Mayo Clinic, Rochester, Minn (P.J.N., S.K.V., R.L.E.); Department of Radiology, Centre Hospitalier de l'Université de Montréal, 1058 Rue Saint-Denis, Montréal, QC, Canada H2X 3J4 (D.O., A.T.); and Department of Radiology, University of California San Diego, San Diego, Calif (C.B.S.).ORCID 0000-0002-6639-9072
An TangFrom the Department of Radiology, University of Washington, Seattle, Wash (G.M.C.); Department of Radiology, Université Laval, Québec, Québec, Canada (B.F.); Department of Radiology, Mayo Clinic, Rochester, Minn (P.J.N., S.K.V., R.L.E.); Department of Radiology, Centre Hospitalier de l'Université de Montréal, 1058 Rue Saint-Denis, Montréal, QC, Canada H2X 3J4 (D.O., A.T.); and Department of Radiology, University of California San Diego, San Diego, Calif (C.B.S.).ORCID 0000-0001-8967-5503
Mayo Clinic in Arizona · USCentre Hospitalier de l’Université de Montréal · CAUniversité Laval · CAUniversity of California San Diego · USUniversity of Washington · US

Funding

Pediatric Trials in Non-Alcoholic Steatohepatitis (NASH)U01DK061734 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROHIT LOOMBA · 2002 to 2026
$24.4M
Technical Validation of MRI Biomarkers of Liver FatR01DK088925 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B., SIRLIN, CLAUDE B · 2010 to 2021
$7.1M
Comprehensive noninvasive assessment of liver histopathology in nonalcoholic fatty liver disease (NAFLD) via magnetic resonance imaging, cytometry and elastography (MR-ICE)R01EB017197 · NIBIB · MAYO CLINIC ROCHESTER · PI YIN, MENG · 2014 to 2025
$4.3M
Magnetic Resonance ElastographyR37EB001981 · NIBIB · MAYO CLINIC ROCHESTER · PI EHMAN, RICHARD L. · 2016 to 2025
$4.0M
QUS Technology for Diagnosis and Grading of Hepatic Steatosis in NAFLDR01DK106419 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LOOMBA, ROHIT, SIRLIN, CLAUDE B · 2015 to 2019
$3.4M
San Diego Cirrhosis Clinical Research NetworkU01DK130190 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROHIT LOOMBA · 2021 to 2026
$2.3M
Fatty liver disease and its determinants in an American Indian Population: the Strong Heart StudyR01DK110096 · NIDDK · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI COLE, SHELLEY A · 2016 to 2018
$2.3M
Quantitative characterization of the liver-pancreas axis in diabetes via multiparametric magnetic resonance elastographyR01DK136731 · NIDDK · MAYO CLINIC ROCHESTER · PI Meng Yin · 2023 to 2026
$1.6M
Noninvasive assessment of portal hypertension and hepatic interstitial pressure with advanced magnetic resonance elastographyR01DK132718 · NIDDK · MAYO CLINIC ROCHESTER · PI Meng Yin · 2023 to 2026
$1.3M
Accurate Point of Care Liver Disease DiagnosticsR43DK135225 · NIDDK · LIVIVOS INC. · PI PRADO, PABLO J, SIRLIN, CLAUDE B · 2022 to 2022
$300k
Qualification of Composite Quantitative Imaging Biomarkers for Diagnostic Enrichment in Nonalcoholic Steatohepatitis (NASH) Clinical Trials (DDTBMQ000112)U01FD007773 · FDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MIDDLETON, MICHAEL S · 2022 to 2022
$250k
FDA HHS U01 FD007773NIBIB NIH HHS R01 EB017197NIBIB NIH HHS R37 EB001981NIDDK NIH HHS R01 DK088925NIDDK NIH HHS R01 DK106419NIDDK NIH HHS R01 DK110096NIDDK NIH HHS R01 DK132718NIDDK NIH HHS R01 DK136731NIDDK NIH HHS R43 DK135225NIDDK NIH HHS U01 DK061734NIDDK NIH HHS U01 DK130190
6 · The paper itself

Abstract

Chronic liver disease is highly prevalent and often leads to fibrosis or cirrhosis and complications such as liver failure and hepatocellular carcinoma. The diagnosis and staging of liver fibrosis is crucial to determine management and mitigate complications. Liver biopsy for histologic assessment has limitations such as sampling bias and high interreader variability that reduce precision, which is particularly challenging in longitudinal monitoring. MR elastography (MRE) is considered the most accurate noninvasive technique for diagnosing and staging liver fibrosis. In MRE, low-frequency vibrations are applied to the abdomen, and the propagation of shear waves through the liver is analyzed to measure liver stiffness, a biomarker for the detection and staging of liver fibrosis. As MRE has become more widely used in clinical care and research, different contexts of use have emerged. This review focuses on the latest developments in the use of MRE for the assessment of liver fibrosis; provides guidance for image acquisition and interpretation; summarizes diagnostic performance, along with thresholds for diagnosis and staging of liver fibrosis; discusses current and emerging clinical applications; and describes the latest technical developments.

Indexed as

Elasticity Imaging TechniquesLiver CirrhosisLiver NeoplasmsAbdomenHumans

Identifiers

PMID38470236
PMCPMC10982829
OpenAlexW4392728184

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.