Evidence map›Paper›PMID 38470554›Full record

ArticleJournal of assisted reproduction and genetics2024

Ovulation induction and subfertile untreated conception groups offer improved options for interpreting risks associated with ART.

Michele Hansen, Roger J Hart, Elizabeth Milne, Carol Bower, Melanie L Walls, John L Yovich, Peter Burton, Yanhe Liu, Hamish Barblett, Anna Kemp-Casey

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
4.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Michele HansenTelethon Kids Institute, UWA Centre for Child Health Research, University of Western Australia, Perth, Australia. Michele.Hansen@uwa.edu.au.ORCID http://orcid.org/0000-0002-6817-2031
Roger J HartDivision of Obstetrics and Gynecology, University of Western Australia, Perth, Australia.ORCID http://orcid.org/0000-0002-6610-3040
Elizabeth MilneTelethon Kids Institute, UWA Centre for Child Health Research, University of Western Australia, Perth, Australia.
Carol BowerTelethon Kids Institute, UWA Centre for Child Health Research, University of Western Australia, Perth, Australia.
Melanie L WallsDivision of Obstetrics and Gynecology, University of Western Australia, Perth, Australia.ORCID http://orcid.org/0000-0003-0729-4737
John L YovichPIVET Medical Centre, Perth, Australia.ORCID http://orcid.org/0000-0002-9583-3683
Peter BurtonConcept Fertility Centre, Perth, Australia.
Yanhe LiuFertility North, Perth, Australia.ORCID http://orcid.org/0000-0001-6276-7010
Hamish BarblettGenea Hollywood Fertility, Perth, Australia.ORCID http://orcid.org/0000-0003-4513-8102
Anna Kemp-CaseyQuality Use of Medicines and Pharmacy Research Centre, University of South Australia, Adelaide, Australia.ORCID http://orcid.org/0000-0002-0018-962X
The Kids Research Institute Australia · AUThe University of Western Australia · AUCurtin University · AUUniversity of South Australia · AU

Funding

National Health and Medical Research Council (AU) 1086530
6 · The paper itself

Abstract

purposeTo identify and characterise appropriate comparison groups for population studies of health outcomes in ART-conceived births: ovulation induction (OI), subfertile untreated and fertile natural conceptions. Our secondary objective was to examine whether known risks of pregnancy complications and adverse birth outcomes in ART births are elevated in comparison with subfertile (untreated and OI) conception groups.

methodsWe linked State and Commonwealth datasets to identify all live and stillbirths (≥ 20 weeks) in Western Australia from 2003 to 2014 by method of conception. Demographic characteristics, maternal pre-existing conditions, adverse obstetric history and pregnancy complications were compared across conception groups. Generalised estimating equations were used to estimate adjusted risk ratios (aRRs) and 95% confidence intervals (CI) for pregnancy complications and birth outcomes in singletons.

resultsWe identified 9456 ART, 3870 OI, 11,484 subfertile untreated and 303,921 fertile naturally conceived deliveries. OI and subfertile untreated groups more closely resembled the ART group than the fertile group; however, some differences remained across parity, maternal age, pre-existing conditions and obstetric history. In multivariate analyses, ART singletons had greater risks of placental problems (e.g. placenta praevia aRR 2.42 (95% CI 1.82-3.20)) and adverse birth outcomes (e.g. preterm birth aRR 1.38 (95% CI 1.25-1.52)) than the subfertile untreated group, while OI singletons were more similar to the subfertile group with higher risk of preeclampsia and gestational diabetes.

conclusionOI and subfertile untreated conception groups offer improved options for interpreting health outcomes in ART births. Pregnancy complications (particularly placental disorders) and adverse outcomes at delivery are more common following ART.

Indexed as

Ovulation InductionPregnancy OutcomeReproductive Techniques, AssistedAdultFemaleFertilizationHumansInfant, NewbornInfertilityMaternal AgePregnancyPregnancy ComplicationsPremature BirthRisk FactorsART outcomesAssisted reproductive technologyIVFOvulation inductionSubfertility

Identifiers

PMID38470554
PMCPMC11052736
OpenAlexW4392715094

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.