Evidence map›Paper›PMID 38470728›Full record

ReviewNanomaterials (Basel, Switzerland)2024

Functionalized ZnO-Based Nanocomposites for Diverse Biological Applications: Current Trends and Future Perspectives.

Ioanna-Aglaia Vagena, Maria-Anna Gatou, Giorgos Theocharous, Pavlos Pantelis, Maria Gazouli, Natassa Pippa, Vassilis G Gorgoulis, Evangelia A Pavlatou, Nefeli Lagopati

Abstract readReview
In one paragraph

Review in Nanomaterials (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ioanna-Aglaia VagenaLaboratory of Biology, Department of Basic Medical Sciences, Medical School, National Kapodistrian University of Athens (NKUA), 11527 Athens, Greece.
Maria-Anna GatouLaboratory of General Chemistry, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, 15772 Athens, Greece.
Giorgos TheocharousMolecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 11527 Athens, Greece.
Pavlos PantelisMolecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 11527 Athens, Greece.
Maria GazouliLaboratory of Biology, Department of Basic Medical Sciences, Medical School, National Kapodistrian University of Athens (NKUA), 11527 Athens, Greece.ORCID 0000-0002-3295-6811
Natassa PippaSection of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National Kapodistrian University of Athens (NKUA), 15771 Athens, Greece.
Vassilis G GorgoulisMolecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 11527 Athens, Greece.ORCID 0000-0001-9001-4112
Evangelia A PavlatouLaboratory of General Chemistry, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, 15772 Athens, Greece.ORCID 0000-0003-3223-4672
Nefeli LagopatiLaboratory of Biology, Department of Basic Medical Sciences, Medical School, National Kapodistrian University of Athens (NKUA), 11527 Athens, Greece.ORCID 0000-0001-9317-9510

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The wide array of structures and characteristics found in ZnO-based nanostructures offers them a versatile range of uses. Over the past decade, significant attention has been drawn to the possible applications of these materials in the biomedical field, owing to their distinctive electronic, optical, catalytic, and antimicrobial attributes, alongside their exceptional biocompatibility and surface chemistry. With environmental degradation and an aging population contributing to escalating healthcare needs and costs, particularly in developing nations, there's a growing demand for more effective and affordable biomedical devices with innovative functionalities. This review delves into particular essential facets of different synthetic approaches (chemical and green) that contribute to the production of effective multifunctional nano-ZnO particles for biomedical applications. Outlining the conjugation of ZnO nanoparticles highlights the enhancement of biomedical capacity while lowering toxicity. Additionally, recent progress in the study of ZnO-based nano-biomaterials tailored for biomedical purposes is explored, including biosensing, bioimaging, tissue regeneration, drug delivery, as well as vaccines and immunotherapy. The final section focuses on nano-ZnO particles' toxicity mechanism with special emphasis to their neurotoxic potential, as well as the primary toxicity pathways, providing an overall review of the up-to-date development and future perspectives of nano-ZnO particles in the biomedicine field.

Indexed as

bioimagingbiomedical applicationsbiosensorsfunctionalizationimmunotherapysynthetic approachestissue engineeringtoxicity mechanismwound healingZnO nanostructures

Identifiers

PMID38470728
PMCPMC10933906

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.