Evidence map›Paper›PMID 38471265›Full record

ArticleProstaglandins, leukotrienes, and essential fatty acids2024

Prostaglandin E2 affects mitochondrial function in adult mouse cardiomyocytes and hearts.

Timothy D Bryson, Matthew Zurek, Carlin Moore, David Taube, Indrani Datta, Albert Levin, Pamela Harding

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Prostaglandins, leukotrienes, and essential fatty acids, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Timothy D BrysonHypertension & Vascular Research Division, Department of Internal Medicine, Henry Ford Health, Detroit, MI, USA.
Matthew ZurekHypertension & Vascular Research Division, Department of Internal Medicine, Henry Ford Health, Detroit, MI, USA.
Carlin MooreHypertension & Vascular Research Division, Department of Internal Medicine, Henry Ford Health, Detroit, MI, USA.
David TaubeHypertension & Vascular Research Division, Department of Internal Medicine, Henry Ford Health, Detroit, MI, USA.
Indrani DattaDepartment of Public Health Sciences, Henry Ford Health, Detroit, MI, USA.
Albert LevinDepartment of Public Health Sciences, Henry Ford Health, Detroit, MI, USA.
Pamela HardingHypertension & Vascular Research Division, Department of Internal Medicine, Henry Ford Health, Detroit, MI, USA; Department of Physiology, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address: phardin1@hfhs.org.
Henry Ford Health System · USWayne State University · US

Funding

Opposing Effects of Prostaglandin E2 EP3 and EP4 Receptors on Mitochondrial Function in the Failing HeartR01HL148060 · NHLBI · WAYNE STATE UNIVERSITY · PI HARDING, PAMELA · 2020 to 2023
$2.2M
NHLBI NIH HHS R01 HL148060
6 · The paper itself

Abstract

Prostaglandin E2 (PGE2) signals differently through 4 receptor subtypes (EP1-EP4) to elicit diverse physiologic/pathologic effects. We previously reported that PGE2 via its EP3 receptor reduces cardiac contractility and male mice with cardiomyocyte-specific deletion of the EP4 receptor (EP4 KO) develop dilated cardiomyopathy. The aim of this study was to identify pathways responsible for this phenotype. We performed ingenuity pathway analysis (IPA) and found that genes differentiating WT mice and EP4 KO mice were significantly overrepresented in mitochondrial (adj. p value = 6.28 × 10

Indexed as

DinoprostoneMice, KnockoutMyocytes, CardiacReceptors, Prostaglandin E, EP4 SubtypeAnimalsMaleMiceMice, Inbred C57BLMitochondriaMitochondria, HeartOxidative PhosphorylationDinoprostonePtger4 protein, mouseReceptors, Prostaglandin E, EP4 SubtypeCardiac metabolismHeart failureMitochondriaOxidative stressPGE2

Identifiers

PMID38471265
PMCPMC11180573
OpenAlexW4392499762

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.