Evidence map›Paper›PMID 38472637›Full record

ReviewPharmacological reports : PR2024

Mechanisms of norcantharidin against renal tubulointerstitial fibrosis.

Qin-Su Yun, Yu-Xin Bao, Jie-Bing Jiang, Qian Guo

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pharmacological reports : PR, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Qin-Su YunDepartment of Pharmacy, The First People's Hospital of Changzhou and the 3rd Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou, 213003, Jiangsu, China.ORCID http://orcid.org/0009-0005-0173-2590
Yu-Xin BaoResearch Center for Medicine and Biology, Zunyi Medical University, 6 West Xuefu Road, Zunyi, 563000, Guizhou, China. baoyuxin8680915@126.com.ORCID http://orcid.org/0000-0003-2467-7019
Jie-Bing JiangDepartment of Pharmacology, Naval Medical University, Shanghai, 200433, China.ORCID http://orcid.org/0009-0006-4664-5164
Qian GuoInstitute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, 881 Yonghe Road, Nantong, 226001 , Jiangsu, China. qian_guo@shu.edu.cn.ORCID http://orcid.org/0000-0002-0768-2628
Shanghai University · CNSoochow University · CNZunyi Medical University · CN

Funding

National Natural Science Foundation of China 82003702Shanghai-Sailing Program 21YF1438000
6 · The paper itself

Abstract

Renal tubulointerstitial fibrosis (RTIF) is a common feature and inevitable consequence of all progressive chronic kidney diseases, leading to end-stage renal failure regardless of the initial cause. Although research over the past few decades has greatly improved our understanding of the pathophysiology of RTIF, until now there has been no specific treatment available that can halt the progression of RTIF. Norcantharidin (NCTD) is a demethylated analogue of cantharidin, a natural compound isolated from 1500 species of medicinal insect, the blister beetle (Mylabris phalerata Pallas), traditionally used for medicinal purposes. Many studies have found that NCTD can attenuate RTIF and has the potential to be an anti-RTIF drug. This article reviews the recent progress of NCTD in the treatment of RTIF, with emphasis on the pharmacological mechanism of NCTD against RTIF.

Indexed as

Kidney DiseasesBridged Bicyclo Compounds, HeterocyclicFibrosisHumansBridged Bicyclo Compounds, HeterocyclicnorcantharidinLong non-coding RNAs (lncRNAs)Norcantharidin (NCTD)Nuclear factor-κB (NF-κB)Protein phosphatase 2A (PP2A)Renal tubulointerstitial fibrosis (RTIF)Transforming growth factor-β1 (TGF-β1)Tumor necrosis factor-like weak inducer of apoptosis (TWEAK)

Identifiers

PMID38472637
OpenAlexW4394762491

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.