Proteomic Analysis Highlights the Impact of the Sphingolipid Metabolizing Enzyme β-Galactosylceramidase on Mitochondrial Plasticity in Human Melanoma.

Davide Capoferri, Luca Mignani, Marcello Manfredi, Marco Presta

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.8field-weighted citation impact, top 29% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

Determination of the Immunomodulatory Role of OTOP2 in Colon Adenocarcinoma.Journal of Cancer · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Davide CapoferriDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-1251-8136

Luca MignaniDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.

Marcello ManfrediDepartment of Translational Medicine, University of Piemonte Orientale, 13100 Novara, Italy.ORCID 0000-0003-0632-5618

Marco PrestaDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-4398-8376

University of Brescia · ITConsorzio Interuniversitario per le Biotecnologie · ITUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · IT

Funding

Consorzio Universitario Biotecnologie CIBItalian Association for Cancer Research IG 23116PNRR M4C2 finanziato dall'Unione Europea-NextGenerationEU Investimento 1.4-CN00000041

6 · The paper itself

Abstract

Mitochondrial plasticity, marked by a dynamism between glycolysis and oxidative phosphorylation due to adaptation to genetic and microenvironmental alterations, represents a characteristic feature of melanoma progression. Sphingolipids play a significant role in various aspects of cancer cell biology, including metabolic reprogramming. Previous observations have shown that the lysosomal sphingolipid-metabolizing enzyme β-galactosylceramidase (GALC) exerts pro-oncogenic functions in melanoma. Here, mining the cBioPortal for a Cancer Genomics data base identified the top 200 nuclear-encoded genes whose expression is negatively correlated with

Indexed as

GalactosylceramidaseMelanomaChromatography, LiquidHumansProteomicsTandem Mass SpectrometryGalactosylceramidasemelanomamitochondrionproteomicssphingolipidsβ-galactosylceramidase

Identifiers

PMID38474307

DOI10.3390/ijms25053062

PMCPMC10931563

OpenAlexW4392506933

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.