Evidence map›Paper›PMID 38474360›Full record

ArticleCells2024

Neuroprotective and Anti-Inflammatory Activities of Hybrid Small-Molecule SA-10 in Ischemia/Reperfusion-Induced Retinal Neuronal Injury Models.

Charles E Amankwa, Lorea Gamboa Acha, Adnan Dibas, Sai H Chavala, Steven Roth, Biji Mathew, Suchismita Acharya

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Mechanisms of action of retinal microglia in diabetic retinopathy (Review).International journal of molecular medicine · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Charles E AmankwaNorth Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Lorea Gamboa AchaDepartment of Anesthesiology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Adnan DibasNorth Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Sai H ChavalaNorth Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Steven RothDepartment of Anesthesiology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-4955-9855
Biji MathewDepartment of Anesthesiology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-3110-3403
Suchismita AcharyaNorth Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.ORCID 0000-0001-5098-5555
University of North Texas · USUniversity of Illinois Chicago · US

Funding

Sex differences in in vitro and in vivo glaucoma models may predict gender specific dose adjustment needsR01EY029823 · NEI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI ACHARYA, SUCHISMITA, STANKOWSKA, DOROTA LUIZA · 2020 to 2024
$2.0M
Novel Cell Free Therapy for GlaucomaR21EY028690 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ROTH, STEVEN · 2019 to 2020
$477k
NEI NIH HHS R01 EY029823NEI NIH HHS R01EY029823NEI NIH HHS R21 EY028690
6 · The paper itself

Abstract

Embolism, hyperglycemia, high intraocular pressure-induced increased reactive oxygen species (ROS) production, and microglial activation result in endothelial/retinal ganglion cell death. Here, we conducted in vitro and in vivo ischemia/reperfusion (I/R) efficacy studies of a hybrid antioxidant-nitric oxide donor small molecule,

methodsTo induce I/R injury and inflammation, we subjected R28 and primary microglial cells to oxygen glucose deprivation (OGD) for 6 h in vitro or treated these cells with a cocktail of TNF-α, IL-1β and IFN-γ for 1 h, followed by the addition of

results

conclusion

Indexed as

Reperfusion InjuryRetinal Ganglion CellsAnimalsAnti-Inflammatory AgentsInflammationIschemiaMiceReactive Oxygen SpeciesReperfusionAnti-Inflammatory AgentsReactive Oxygen Specieshybrid antioxidantsinflammationischemia reperfusionmicroglianeuronal cell deathNO donoroxidative stressretinopathySA-10

Identifiers

PMID38474360
PMCPMC10931063
OpenAlexW4392168799

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.