Evidence map›Paper›PMID 38475764›Full record

Trial reportBMC musculoskeletal disorders2024

Intra-articular injection of gold micro-particles with hyaluronic acid for painful knee osteoarthritis.

Sten Rasmussen, Kristian Kjaer Petersen, Christopher Aboo, Jacob Skallerup Andersen, Emilie Skjoldemose, Nia Kristine Jørgensen, Allan Stensballe, Lars Arendt-Nielsen

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC musculoskeletal disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03389906 (Inflammation Impact on Pain in Patients With Knee Osteoarthritis), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03389906 nacompletednot on this map

Inflammation Impact on Pain in Patients With Knee Osteoarthritis

TypeinterventionalSponsorSten Rasmussen, MD, PhDRan2017 to 2020Enrolled32ConditionsInflammation, Osteo Arthritis KneeArmsGold
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. How Selective are Nanomaterials to Treat Osteoarthritis.International journal of nanomedicine · 2026
    Review
  7. Review
  8. Gold Nanoparticles for Wound Healing in Animal Models.Nanomaterials (Basel, Switzerland) · 2025
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sten RasmussenDepartment of Clinical Medicine, Aalborg University, 249 Selma Lagerløfs Vej, Gistrup, 9260, Denmark. sten@dcm.aau.dk.
Kristian Kjaer PetersenDepartment of Health Science and Technology, Aalborg University, Aalborg, Denmark.
Christopher AbooDepartment of Health Science and Technology, Aalborg University, Aalborg, Denmark.
Jacob Skallerup AndersenDepartment of Health Science and Technology, Aalborg University, Aalborg, Denmark.
Emilie SkjoldemoseDepartment of Clinical Medicine, Aalborg University, 249 Selma Lagerløfs Vej, Gistrup, 9260, Denmark.
Nia Kristine JørgensenDepartment of Clinical Medicine, Aalborg University, 249 Selma Lagerløfs Vej, Gistrup, 9260, Denmark.
Allan StensballeDepartment of Clinical Medicine, Aalborg University, 249 Selma Lagerløfs Vej, Gistrup, 9260, Denmark.
Lars Arendt-NielsenDepartment of Health Science and Technology, Aalborg University, Aalborg, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecently, in an open pilot study, we found up to two years, a potential pain-relieving effect of intra-articular gold micro-particles using the patient's synovial fluid for patients with knee osteoarthritis (KOA). During the study the excluded group of patients, due to multisite pain, co-morbidities, and other exclusion criteria., received intra-articular gold micro-particles using hyaluronic acid,. We aimed to identify if pre-treatment characteristics influence the global outcome two years after intra-articular treatment for painful KOA with gold microparticles using hyaluronic acid.

methodsUsing hyaluronic acid as the carrier, 136 patients with KOA received intraarticular injections with 20 mg gold microparticles (72.000 particles, 20-40 μm in diameter). In the analysis, we included the Global Rating of Change Scale, Pain Detect Questionnaire (PDQ), Body Mass Index (BMI), and Kellgren & Lawrence score at the inclusion, Western Ontario, and McMaster Universities Osteoarthritis Index (WOMAC) sub-scores for pain, stiffness, and function at inclusion and two years.

resultsOn the Global Rating Change Scale, 69.1% of patients reported a positive effect, 28.7% no effect, and 2.2% worse. PDQ and the three WOMAC subscores all improved at two years of follow-up. PDQ ≥ 13 (P = 0.028), BMI (P = 0.022) and Kellgren & Lawrence grade 4 (P = 0.028) at inclusion reduced the effect with a minor odds ratio compared to the baseline effect of treatment (P = 0.025). WOMAC subscores at inclusion did not influence the outcome (P > 0.5).

conclusionsSevere osteoarthritis, obesity, and neuropathic pain, reduced the effect of intra-articular gold microparticles for knee OA.

trial registrationThe study followed the principles of the Declaration of Helsinki and was approved by the local ethics committee of the North Denmark Region by 27/07/2016 (N-20,160,045). The regional data protection agency approved the project by 06/07/2016 (2008-58-0028, ID 2016 - 116) and registered in ClinicalTrial.Gov by 04/01/2018 (NCT03389906).

Indexed as

NeuralgiaOsteoarthritis, KneeHumansHyaluronic AcidInjections, Intra-ArticularPilot ProjectsTreatment OutcomeHyaluronic AcidGold microparticlesHyaluronic acidIntra-articular injectionKnee osteoarthritisOutcomes

Identifiers

PMID38475764
PMCPMC10935980

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.