Evidence map›Paper›PMID 38475789›Full record

ArticleBMC oral health2024

Effect of the antirheumatic medication methotrexate (MTX) on biomechanical compressed human periodontal ligament fibroblasts (hPDLFs).

Claudia Welte-Jzyk, Vera Plümer, Sven Schumann, Andrea Pautz, Christina Erbe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.0field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Claudia Welte-Jzyk *Department of Orthodontics, University Medical Center of the Johannes Gutenberg-University, 55131, Mainz, Germany. Claudia.Welte-Jzyk@unimedizin-mainz.de.
Vera Plümer *Department of Orthodontics, University Medical Center of the Johannes Gutenberg-University, 55131, Mainz, Germany.
Sven SchumannInstitute of Anatomy, University Medical Center of the Johannes Gutenberg-University Mainz, 55128, Mainz, Germany.
Andrea PautzDepartment of Pharmacology, University Medical Center of the Johannes Gutenberg University, 55131, Mainz, Germany.
Christina ErbeDepartment of Orthodontics, University Medical Center of the Johannes Gutenberg-University, 55131, Mainz, Germany.
University Medical Center of the Johannes Gutenberg University Mainz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to investigate the in vitro effect of the antirheumatic drug methotrexate (MTX) on biomechanically compressed human periodontal ligament fibroblasts (hPDLFs), focusing on the expression of interleukin 6 (IL-6), as its upregulation is relevant to orthodontic tooth movement.

methodsHuman PDLFs were subjected to pressure and simultaneously treated with MTX. Cell proliferation, viability and morphology were studied, as was the gene and protein expression of IL-6.

resultsCompared with that in untreated fibroblasts, IL-6 mRNA expression in mechanically compressed ligament fibroblasts was increased (two to sixfold; ****p < 0.0001). Under compression, hPDLFs exhibited a significantly more expanded shape with an increase of cell extensions. MTX with and without pressure did not affect IL-6 mRNA expression or the morphology of hPDLFs.

conclusionMTX has no effect on IL-6 expression in compressed ligament fibroblasts.

Indexed as

Antirheumatic AgentsMethotrexateCells, CulturedFibroblastsHumansInterleukin-6Periodontal LigamentRNA, MessengerAntirheumatic AgentsInterleukin-6MethotrexateRNA, MessengerHuman periodontal ligament fibroblastMethotrexateOrthodontic compressionRheumatoid arthritis

Identifiers

PMID38475789
PMCPMC10936030
OpenAlexW4392755294

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.