Evidence map›Paper›PMID 38476227›Full record

ReviewFrontiers in immunology2024

Combined islet and kidney xenotransplantation for diabetic nephropathy: an update in ongoing research for a clinically relevant application of porcine islet transplantation.

Daniel L Eisenson, Hayato Iwase, Weili Chen, Yu Hisadome, Wanxing Cui, Michelle R Santillan, Alexander C Schulick, Du Gu, Amanda Maxwell, Kristy Koenig and 3 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Daniel L EisensonDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Hayato IwaseDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Weili ChenDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Yu HisadomeDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Wanxing CuiCell Therapy and Manufacturing, Medstar Georgetown University Hospital, Washington DC, United States.
Michelle R SantillanDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Alexander C SchulickDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Du GuDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Amanda MaxwellResearch Animal Resources, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Kristy KoenigDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Zhaoli SunDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Daniel WarrenDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Kazuhiko YamadaDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Johns Hopkins Medicine · USJohns Hopkins University · USMedStar Georgetown University Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Combined islet and kidney xenotransplantation for the treatment of diabetic nephropathy represents a compelling and increasingly relevant therapeutic possibility for an ever-growing number of patients who would benefit from both durable renal replacement and cure of the underlying cause of their renal insufficiency: diabetes. Here we briefly review immune barriers to islet transplantation, highlight preclinical progress in the field, and summarize our experience with combined islet and kidney xenotransplantation, including both challenges with islet-kidney composite grafts as well as our recent success with sequential kidney followed by islet xenotransplantation in a pig-to-baboon model.

Indexed as

Diabetes Mellitus, Type 1Diabetic NephropathiesIslets of Langerhans TransplantationAnimalsHumansKidneySwineTransplantation, Heterologousislet-kidneyislet xenotransplantationtolerancexenogeneic immune responsexenotransplantation

Identifiers

PMID38476227
PMCPMC10927755
OpenAlexW4392195626

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.