Evidence mapPaperPMID 38476331Full record

ReviewFrontiers in pharmacology2024

Non-coding RNAs: targets for Chinese herbal medicine in treating myocardial fibrosis.

Minghui Wang, Maocai Yan, Liqiang Tan, Xiaona Zhao, Guoqing Liu, Zejin Zhang, Jing Zhang, Honggang Gao, Wei Qin

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Minghui Wang *School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Maocai Yan *School of Pharmacy, Jining Medical University, Rizhao, Shandong, China.
Liqiang TanDepartment of Nasopharyngeal Carcinoma, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China.
Xiaona ZhaoSchool of Pharmacy, Jining Medical University, Rizhao, Shandong, China.
Guoqing LiuSchool of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Zejin ZhangSchool of Pharmacy, Jining Medical University, Rizhao, Shandong, China.
Jing ZhangSchool of Pharmacy, Jining Medical University, Rizhao, Shandong, China.
Honggang GaoSchool of Pharmacy, Jining Medical University, Rizhao, Shandong, China.
Wei QinSchool of Pharmacy, Jining Medical University, Rizhao, Shandong, China.
Jining Medical University · CNBinzhou Medical University · CNShandong University of Traditional Chinese Medicine · CNSun Yat-sen University Cancer Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular diseases have become the leading cause of death in urban and rural areas. Myocardial fibrosis is a common pathological manifestation at the adaptive and repair stage of cardiovascular diseases, easily predisposing to cardiac death. Non-coding RNAs (ncRNAs), RNA molecules with no coding potential, can regulate gene expression in the occurrence and development of myocardial fibrosis. Recent studies have suggested that Chinese herbal medicine can relieve myocardial fibrosis through targeting various ncRNAs, mainly including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). Thus, ncRNAs are novel drug targets for Chinese herbal medicine. Herein, we summarized the current understanding of ncRNAs in the pathogenesis of myocardial fibrosis, and highlighted the contribution of ncRNAs to the therapeutic effect of Chinese herbal medicine on myocardial fibrosis. Further, we discussed the future directions regarding the potential applications of ncRNA-based drug screening platform to screen drugs for myocardial fibrosis.

Indexed as

Chinese herbal medicinecircRNAslncRNAsmiRNAsmyocardial fibrosisncRNAs

Identifiers

PMID38476331
PMCPMC10928947
OpenAlexW4392198622

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.