Evidence map›Paper›PMID 38477234›Full record

ArticlePediatric obesity2024

Associations of radiologic characteristics of the neonatal hypothalamus with early life adiposity gain.

Leticia E Sewaybricker, Susan J Melhorn, Sonja Entringer, Claudia Buss, Pathik D Wadhwa, Ellen A Schur, Jerod M Rasmussen

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric obesity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Leticia E SewaybrickerDepartment of Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-1904-9499
Susan J MelhornDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Sonja EntringerDevelopment, Health and Disease Research Program, University of California, Irvine, California, USA.
Claudia BussDevelopment, Health and Disease Research Program, University of California, Irvine, California, USA.
Pathik D WadhwaDevelopment, Health and Disease Research Program, University of California, Irvine, California, USA.
Ellen A SchurDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Jerod M RasmussenDevelopment, Health and Disease Research Program, University of California, Irvine, California, USA.
University of California, Irvine · USUniversity of Washington · US

Funding

PILOT STUDY--CLINICAL NUTRITION RESEARCHP30DK035816 · NIDDK · UNIVERSITY OF WASHINGTON · PI Ellen A Schur · 1986 to 2026
$30.4M
A twin study of obesity pathogenesis using fMRIR01DK089036 · NIDDK · UNIVERSITY OF WASHINGTON · PI SCHUR, ELLEN A · 2011 to 2022
$6.2M
Impact of hypothalamic gliosis on appetite regulation and obesity risk in childrenR01DK117623 · NIDDK · UNIVERSITY OF WASHINGTON · PI SCHUR, ELLEN A · 2019 to 2023
$3.7M
EMA Assessment of Biobehavioral Processes in Human PregnancyR01HD060628 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WADHWA, PATHIK D · 2010 to 2014
$3.4M
FETAL PROGRAMMING OF THE NEWBORN AND INFANT HUMAN BRAINR01MH091351 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BUSS, CLAUDIA, WADHWA, PATHIK D · 2011 to 2015
$3.3M
Prenatal stress biology, infant body composition and obesity riskR01HD065825 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI ENTRINGER, SONJA, WADHWA, PATHIK D · 2010 to 2014
$2.2M
Fostering patient-oriented research in cardiometabolic disease pathogenesis and preventionK24HL144917 · NHLBI · UNIVERSITY OF WASHINGTON · PI Ellen A Schur · 2019 to 2026
$965k
Fetal Programming of Human Newborn Energy Homeostasis Brain NetworksR00HD100593 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI RASMUSSEN, JEROD MICHAEL · 2023 to 2025
$744k
Human Newborn Energy Homeostasis Brain Networks And Infant AdiposityR21DK118578 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI THOMPSON, PAUL M, WADHWA, PATHIK D · 2019 to 2020
$351k
NHLBI NIH HHS K24 HL144917NICHD NIH HHS R00 HD100593NICHD NIH HHS R01 HD060628NICHD NIH HHS R01 HD065825NIDDK NIH HHS K24HL144917NIDDK NIH HHS P30 DK035816NIDDK NIH HHS R01 DK089036NIDDK NIH HHS R01 DK117623NIDDK NIH HHS R21 DK118578NIMH NIH HHS R01 MH091351
6 · The paper itself

Abstract

backgroundThe mediobasal hypothalamus (MBH) is a key brain area for regulation of energy balance. Previous neuroimaging studies suggest that T2-based signal properties indicative of cellular inflammatory response (gliosis) are present in adults and children with obesity, and predicts greater adiposity gain in children at risk of obesity. OBJECTIVES/

methodsThe current study aimed to extend this concept to the early life period by considering if, in full-term healthy neonates (up to n = 35), MRI evidence of MBH gliosis is associated with changes in early life (neonatal to six months) body fat percentage measured by DXA.

resultsIn this initial study, neonatal T2 signal in the MBH was positively associated with six-month changes in body fat percentage.

conclusionThis finding supports the notion that underlying processes in the MBH may play a role in early life growth and, by extension, childhood obesity risk.

Indexed as

AdiposityHypothalamusMagnetic Resonance ImagingPediatric ObesityAbsorptiometry, PhotonBody Mass IndexFemaleHumansInfantInfant, NewbornMaleWeight Gaingliosishypothalamusinfantmagnetic resonance imagingnewbornpaediatric obesity

Identifiers

PMID38477234
PMCPMC11081834
OpenAlexW4392741498

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.