Evidence map›Paper›PMID 38478261›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2024

Assessment of TUFT1 and Rac1-GTP levels in triple-negative breast cancer patients: clinical and pathological correlations.

Su-Fang Shi, Rui-Xi Cai, Yan-Fei Ren, Yong Li, Shuo Li, Tian-Lu Yin, Dong-Xiao Jia, Yong-Jun Li

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Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Su-Fang Shi *Department of Breast Surgery, The Affiliated Hospital of Hebei Engineering University, Handan, 056000, Hebei, China.
Rui-Xi Cai *Department of Anorectal, Handan Hospital of Traditional Chinese Medicine, Handan, 056000, Hebei, China.
Yan-Fei RenOperating Room, The Affiliated Hospital of Hebei Engineering University, Handan, 056000, Hebei, China.
Yong LiOperating Room, The Second Hospital of Handan, Handan, 056000, Hebei, China.
Shuo LiDepartment of Breast Surgery, The Affiliated Hospital of Hebei Engineering University, Handan, 056000, Hebei, China.
Tian-Lu YinInstitute of Medical Information, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100000, China.
Dong-Xiao JiaDepartment of Breast Surgery, The Affiliated Hospital of Hebei Engineering University, Handan, 056000, Hebei, China.
Yong-Jun LiDepartment of Medical Imaging, The Affiliated Hospital of Hebei Engineering University, No. 81 Congtai Road, Congtai District, Handan, 056000, Hebei, China. yongjunlilyj05@126.com.ORCID http://orcid.org/0009-0005-1130-2746
Hebei University of Engineering · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNHandan College · CN

Funding

2021 Hebei Medical science research project plan No.20210206
6 · The paper itself

Abstract

objectiveThe primary goal of this study was to investigate the expressions of TUFT1 (Tuftelin) and Rac1-GTP in the cancerous tissues of individuals with triple-negative breast cancer (TNBC). Additionally, we aimed to explore the correlation between TUFT1 and Rac1-GTP expressions and examine the associations of TUFT1 and Rac1-GTP expressions with the clinical and pathological indicators of the patients.

methodsNinety-six patients diagnosed with TNBC, scheduled for surgery between May 2022 and November 2022, were enrolled in this study. Cancerous tissue specimens were collected from these patients, and immunohistochemistry was employed to evaluate the levels of TUFT1 and Rac1-GTP expressions in the cancerous tissues. Subsequent to data collection, a comprehensive analysis was conducted to examine the correlation between TUFT1 and Rac1-GTP expressions. Furthermore, we sought to assess the associations of TUFT1 and Rac1-GTP expressions with the clinical and pathological indicators of the patients.

resultsThe TUFT1 protein was expressed in both the membrane and cytoplasm of TNBC cancer cells, with notably higher expression observed in the cytoplasm. Rac1-GTP was primarily expressed in the cytoplasm. There was a positive correlation between the levels of TUFT1 and Rac1-GTP expressions (χ

conclusionA significant correlation was identified between the levels of TUFT1 and Rac1-GTP expressions in the cancerous tissues of patients with TNBC, suggesting a close association with the progression of TNBC. The two molecules play significant roles in facilitating an early diagnosis and treatment of TNBC.

Indexed as

rac1 GTP-Binding ProteinTriple Negative Breast NeoplasmsAdultAgedBiomarkers, TumorCytoplasmFemaleHumansImmunohistochemistryLymphatic MetastasisMiddle AgedBiomarkers, Tumorrac1 GTP-Binding ProteinRAC1 protein, humanClinical pathological indicatorsRac1-GTPTriple-negative breast cancer (TNBC)TUFT1

Identifiers

PMID38478261
OpenAlexW4392751442

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.