ArticleNature2024
Rapid unleashing of macrophage efferocytic capacity via transcriptional pause release.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 28 citations in OpenAlex.
- Muscularis EGR1 Deficiency Impairs M2 Macrophage Polarization and Disrupts Gastric Motility in Diabetic Gastroparesis.Neurogastroenterology and motility · 2026Article
- Macrophage programming in systemic sclerosis: Niches, networks, and translational horizons.Seminars in immunopathology · 2026Review
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- Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar-Limited Repair in Adult Spinal Cord Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Incorporating WGCNA and Machine Learning to Identify ADAP2 as a Critical Efferocytosis-Related Gene in Sepsis.Pathogens (Basel, Switzerland) · 2026Article
- Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post-Operative Osteosarcoma Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Cell death modalities modulate inflammatory and regenerative programs in zebrafish sensory organs.Nature communications · 2026Article
- Targeting GPR34 in damage-associated macrophages enhances anti-tumor immunity and the efficacy of Surufatinib in pancreatic cancer.Signal transduction and targeted therapy · 2026Article
- Obesity Disrupts H3K4me3-Mediated Lactate Accumulation and Efferocytosis in Hypoxic Macrophages.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Synthetic cleavage-resistant TREM2 boosts macrophage efferocytosis to treat inflammatory diseases.Cell reports. Medicine · 2026Article
- Compromised hepatic bilirubin clearance drives depressive symptoms via regulating microglial engulfment of dendritic spines.Journal of neuroinflammation · 2026Article
- Remodeling the tumor immune microenvironment: mechanisms of crosstalk between regulated cell death macrophages.Frontiers in immunology · 2026Review
- Defective RNA processing and ELOA-mediated transcriptional elongation in reversible cellular senescence suggest aging by transcription.Molecular cell · 2025Article
- Hypoxic migrasomes drive colorectal cancer liver metastasis by mediating CD5LJournal of translational medicine · 2025Article
- Exploring CAR-macrophages in non-tumor diseases: Therapeutic potential beyond cancer.Journal of advanced research · 2025Review
- Article
- Caloric restriction promotes resolution of atherosclerosis in obese mice, while weight regain accelerates its progression.The Journal of clinical investigation · 2025Article
- EGR2 maintains neuropathic pain by promoting microglial phagocytosis.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- Dys-regulated phosphatidylserine externalization as a cell intrinsic immune escape mechanism in cancer.Cell communication and signaling : CCS · 2025Review
- Antigen-presenting fibroblasts: emerging players in immune modulation and therapeutic targets.Theranostics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 5 institutions in 3 countries.
Turan TufanDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Gamze ComertpayDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Ambra VillaniDepartment of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-4468-6353
Geoffrey M NelsonDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-9825-4241
Marina TerekhovaDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Shannon KelleyDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Pavel ZakharovDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Rochelle M EllisonDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-2080-5837
Oleg ShpynovDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Michael RaymondDepartment of Neuroscience and MIC, University of Virginia, Charlottesville, VA, USA.
Jerry SunDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Yitan ChenDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-9868-3097
Enno BockelmannDepartment of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-8597-7811
Marta StremskaDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Lance W PetersonDepartment of Pediatrics, Division of Rheumatology and Immunology, Washington University in St. Louis, St. Louis, MO, USA.
Laura BoeckaertsUnit for Cell Clearance in Health and Disease, VIB-UGent Center for Inflammation Research and the Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Seth R GoldmanDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-5096-3778
J Iker EtchegarayDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Maxim N ArtyomovDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-1133-4212
Francesca PeriDepartment of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
Kodi S RavichandranDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. kodi@wustl.edu.ORCID 0000-0001-9049-1410
Washington University in St. Louis · USUniversity of Zurich · CHHarvard University · USUniversity of Virginia · USVIB-UGent Center for Inflammation Research · BE
Funding
TRAINING PROGRAM IN IMMUNOLOGY AND IMMUNOGENETICST32AI007163 · NIAID · WASHINGTON UNIVERSITY · PI Kenneth M Murphy, Kodi S Ravichandran · 1985 to 2026
$14.8MSolute carrier proteins in efferocytosis and inflammationR01AI159551 · NIAID · WASHINGTON UNIVERSITY · PI RAVICHANDRAN, KODI S · 2021 to 2025
$2.9MSolute carrier proteins and metal ion-based signaling during efferocytosisR37AI159551 · NIAID · WASHINGTON UNIVERSITY · PI Kodi S Ravichandran · 2026 to 2026
$611kInsulin, a new role in retinal homeostasis and diseaseF32EY031211 · NEI · UNIVERSITY OF VIRGINIA · PI ETCHEGARAY, JON IKER · 2020 to 2021
$142kTesting the tyrosine phosphatase SHP-2 as a novel brake on efferocytosisF31HL160134 · NHLBI · WASHINGTON UNIVERSITY · PI KELLEY, SHANNON · 2021 to 2023
$107kAmerican Heart Association-American Stroke Association 835593NEI NIH HHS F32 EY031211NHLBI NIH HHS F31 HL160134NIAID NIH HHS R01 AI159551NIAID NIH HHS R37 AI159551NIAID NIH HHS T32 AI007163
Abstract
During development, inflammation or tissue injury, macrophages may successively engulf and process multiple apoptotic corpses via efferocytosis to achieve tissue homeostasis
Indexed as
EfferocytosisMacrophagesRNA Polymerase IITranscription Elongation, GeneticAnimalsApoptosisCytoskeletonEarly Growth Response Protein 3HumansHydrogen-Ion ConcentrationMaleMiceNeuronsPhagosomesTime FactorsTranscription FactorsEarly Growth Response Protein 3EGR3 protein, humanEgr3 protein, mouseRNA Polymerase IITranscription Factors
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.