Evidence map›Paper›PMID 38481780›Full record

ArticleAnnals of gastroenterology

Fibrin glue and coats compromise the integrity of colonic anastomosis: an experimental trial on rats.

Nikolaos Voloudakis, Ioannis Koutelidakis, Emmanouil Christoforidis, Stefanos Atmatzidis, Georgia Kotoreni, Basilios Papaziogas, Dimitrios Schizas, Christos Zavos, Apostolos Papalois, Grigorios Chatzimavroudis

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PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Nikolaos VoloudakisSecond Surgical Department, G. Gennimatas Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Ioannis KoutelidakisSecond Surgical Department, G. Gennimatas Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Emmanouil ChristoforidisSecond Surgical Department, G. Gennimatas Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Stefanos AtmatzidisSecond Surgical Department, G. Gennimatas Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Georgia KotoreniSecond Surgical Department, G. Gennimatas Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Basilios PapaziogasSecond Surgical Department, G. Gennimatas Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Dimitrios SchizasFirst Surgical Department, Laikon General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Christos ZavosSecond Medical Clinic, Ippokration Hospital, School of Medicine, Aristotle University of Thessaloniki, Macedonia, Greece.
Apostolos PapaloisExperimental, Educational and Research Center (ELPEN), Pikermi, Athens, Greece.
Grigorios ChatzimavroudisSecond Surgical Department, G. Gennimatas Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Aristotle University of Thessaloniki · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Anastomotic leak remains a dreaded complication in colorectal surgery. Identifying optimal techniques that minimize its incidence is an active area of investigation. The aim of this experimental study was to evaluate the effect of commonly used hemostatic products on the integrity of colonic anastomoses. Methods: Male Wistar rats were randomized into 4 groups. In the control group (A), the anastomosis was performed using the standard hand-sewn technique in the ascending colon. In group B the hand-sewn technique was reinforced with a collagen-fibrinogen patch, in group C with fibrin glue, and in group D with a polyethylene glycol (PEG)-coated oxidized cellulose patch. On the 7 Results: Of the 19 rats, 17 survived and 15 were included in the analysis (5 in each of groups A, B and C). Testing in group D was discontinued following adverse events in the preliminary experiments. The mean bursting pressure of the anastomosis was significantly higher in the control group (A: 221±19.41 mmHg, B: 151±14.42 mmHg, and C: 112±13.57 mmHg; P=0.001). Anastomotic healing parameters were not different between groups. Conclusions: Although experimental data support the use of sealants in defective anastomoses, in this study the reinforcement of colonic anastomosis with fibrin or oxidized cellulose-PEG sealants did not improve either bursting pressure values or anastomotic healing. More data from robust anastomoses of animals and humans are needed before sealing becomes common clinical practice in colorectal surgery.

Indexed as

Anastomotic bursting pressureanastomotic leakcollagen patchcolonic anastomosisfibrin glue

Identifiers

PMID38481780
PMCPMC10927628
OpenAlexW4392007080

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.