Evidence map›Paper›PMID 38483745›Full record

ArticleInternational microbiology : the official journal of the Spanish Society for Microbiology2024

Exposure of Cryptococcus neoformans to low nitrogen levels enhances virulence.

Caylin Bosch, Barbra Toplis, Anton DuPreez Van Staden, Heinrich Volschenk, Carine Smith, Leon Dicks, Alfred Botha

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International microbiology : the official journal of the Spanish Society for Microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Caylin BoschDepartment of Microbiology, University of Stellenbosch, Private Bag X1, Matieland, Stellenbosch, 7602, South Africa.
Barbra ToplisDepartment of Microbiology, University of Stellenbosch, Private Bag X1, Matieland, Stellenbosch, 7602, South Africa.
Anton DuPreez Van StadenDepartment of Microbiology, University of Stellenbosch, Private Bag X1, Matieland, Stellenbosch, 7602, South Africa.
Heinrich VolschenkDepartment of Microbiology, University of Stellenbosch, Private Bag X1, Matieland, Stellenbosch, 7602, South Africa.
Carine SmithDivision of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, University of Stellenbosch, Stellenbosch, South Africa.
Leon DicksDepartment of Microbiology, University of Stellenbosch, Private Bag X1, Matieland, Stellenbosch, 7602, South Africa.
Alfred BothaDepartment of Microbiology, University of Stellenbosch, Private Bag X1, Matieland, Stellenbosch, 7602, South Africa. abo@sun.ac.za.
Stellenbosch University · ZA

Funding

National Research Foundation (NRF) of South Africa Grant Number: 129277
6 · The paper itself

Abstract

Previous studies have shown a correlation between nitrogen levels and Cryptococcus neoformans pathogenicity. Here we report on the in vivo effects of cryptococcal pre-exposure to ecologically relevant nitrogen levels. C. neoformans H99 was cultured in yeast carbon base (YCB) supplemented with 0.53 g/L NH

Indexed as

CryptococcosisCryptococcus neoformansLarvaMacrophagesMothsNitrogenAnimalsCulture MediaVirulenceCulture MediaNitrogenCryptococcus neoformansGalleria mellonellaMacrophagesNitrogen limitationTitanisation

Identifiers

PMID38483745
PMCPMC11452460
OpenAlexW4392817907

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.