Evidence map›Paper›PMID 38486006›Full record

ArticleScientific reports2024

Ultra-high throughput-based screening for the discovery of antiplatelet drugs affecting receptor dependent calcium signaling dynamics.

Delia I Fernández, Sara Troitiño, Vladimír Sobota, Bibian M E Tullemans, Jinmi Zou, Helma van den Hurk, Ángel García, Saman Honarnejad, Marijke J E Kuijpers, Johan W M Heemskerk

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Platelet spreading and clot retraction are regulated by 2 distinct αThe Journal of pharmacology and experimental therapeutics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Delia I FernándezThe Department of Biochemistry, CARIM, Maastricht University, 6229 ER, Maastricht, The Netherlands.
Sara Troitiño *Platelet Proteomics Group, CiMUS, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Vladimír Sobota *IHU-LIRYC, Electrophysiology and Heart Modeling Institute, Fondation Bordeaux Université, 33604, Bordeaux, France.
Bibian M E TullemansThe Department of Biochemistry, CARIM, Maastricht University, 6229 ER, Maastricht, The Netherlands.
Jinmi ZouThe Department of Biochemistry, CARIM, Maastricht University, 6229 ER, Maastricht, The Netherlands.
Helma van den HurkPivot Park Screening Centre, 5349 AB, Oss, The Netherlands.
Ángel GarcíaPlatelet Proteomics Group, CiMUS, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Saman HonarnejadPivot Park Screening Centre, 5349 AB, Oss, The Netherlands.
Marijke J E KuijpersThe Department of Biochemistry, CARIM, Maastricht University, 6229 ER, Maastricht, The Netherlands. marijke.kuijpers@maastrichtuniversity.nl.
Johan W M HeemskerkThe Department of Biochemistry, CARIM, Maastricht University, 6229 ER, Maastricht, The Netherlands. jwmheem722@outlook.com.
Synapse (Netherlands) · NLUniversidade de Santiago de Compostela · ESCenter for Research in Molecular Medicine and Chronic Diseases · ESInstitut de Mathématiques de Bordeaux · FRMaastricht University · NLMaastricht University Medical Centre · NL

Funding

Agence Nationale de la Recherche ANR-10-IAHU-04China Scholarship Council 201909370052European Union's Horizon 2020 research and innovation program under the Marie Slodowska-Curie grant agreement 76118
6 · The paper itself

Abstract

Distinct platelet activation patterns are elicited by the tyrosine kinase-linked collagen receptor glycoprotein VI (GPVI) and the G-protein coupled protease-activated receptors (PAR1/4) for thrombin. This is reflected in the different platelet Ca

Indexed as

CalciumPhenothiazinesPlatelet Aggregation InhibitorsBlood PlateletsCalcium, DietaryCalcium SignalingHumansPlatelet ActivationPlatelet AggregationPlatelet Membrane GlycoproteinsReceptor, PAR-1ThrombinCalciumCalcium, DietaryPhenothiazinesPlatelet Aggregation InhibitorsPlatelet Membrane GlycoproteinsprofenamineReceptor, PAR-1ThrombinCollagenCytosolic calciumGlycoprotein VIPrestwick libraryThrombinThrombosis

Identifiers

PMID38486006
PMCPMC10940705
OpenAlexW4392797733

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.