Evidence map›Paper›PMID 38486305›Full record

ReviewItalian journal of pediatrics2024

Italian guidelines for the management of irritable bowel syndrome in children and adolescents : Joint Consensus from the Italian Societies of: Gastroenterology, Hepatology and Pediatric Nutrition (SIGENP), Pediatrics (SIP), Gastroenterology and Endoscopy (SIGE) and Neurogastroenterology and Motility (SINGEM).

Giovanni Di Nardo, Giovanni Barbara, Osvaldo Borrelli, Cesare Cremon, Valentina Giorgio, Luigi Greco, Michele La Pietra, Giovanni Marasco, Licia Pensabene, Marisa Piccirillo and 9 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Italian journal of pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
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  11. Integrative and Complementary Health Practices for Chronic Pain: summary of clinical guideline recommendations.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 11 institutions in 2 countries.

Giovanni Di NardoDepartment of Neurosciences, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital, Rome, Italy.
Giovanni BarbaraIRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, 40126, Italy.
Osvaldo BorrelliNeurogastroenterology & Motility Unit, Gastroenterology Department, Great Ormond Street Hospital for Children, London, UK.
Cesare CremonIRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, 40126, Italy.
Valentina GiorgioDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Luigi GrecoGeneral Pediatrician, Heath Care Agency of Bergamo, Bergamo, Italy.
Michele La PietraGeneral Pediatrician, Heath Care Agency of Naples, Naples, Italy.
Giovanni MarascoIRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, 40126, Italy.
Licia PensabeneDepartment of Medical and Surgical Sciences, Pediatric Unit, Magna Graecia University, Catanzaro, Italy.
Marisa PiccirilloDepartment of Neurosciences, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital, Rome, Italy.
Claudio RomanoPediatric Gastroenterology and Cystic Fibrosis Unit, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Messina, Italy.
Silvia SalvatorePediatric Department, "F. Del Ponte" Hospital, University of Insubria, Varese, Italy.
Michele SavianoGeneral Pediatrician, Heath Care Agency of Naples, Naples, Italy.
Vincenzo StanghelliniIRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, 40126, Italy.
Caterina StrisciuglioDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Renato TambucciDigestive Endoscopy and Surgery Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Rossella TurcoDepartment of Pediatrics, Santobono-Pausilipon Children's Hospital, Naples, Italy.
Letizia ZenzeriDepartment of Neurosciences, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital, Rome, Italy.
Annamaria StaianoDepartment of Translational Medical Science, Section of Pediatrics, University Federico II, Via S. Pansini 5, Naples, 80131, Italy. Annamaria.staiano@unina.it.ORCID http://orcid.org/0000-0003-0586-1339
Azienda USL di Bologna · ITSapienza University of Rome · ITBambino Gesù Children's Hospital · ITFederico II University Hospital · ITGreat Ormond Street Hospital · GBMagna Graecia University · ITSantobono Children's Hospital · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Insubria · ITUniversity of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The irritable bowel syndrome (IBS) is a functional gastrointestinal disorder (FGID), whose prevalence has widely increased in pediatric population during the past two decades. The exact pathophysiological mechanism underlying IBS is still uncertain, thus resulting in challenging diagnosis and management. Experts from 4 Italian Societies participated in a Delphi consensus, searching medical literature and voting process on 22 statements on both diagnosis and management of IBS in children. Recommendations and levels of evidence were evaluated according to the grading of recommendations, assessment, development, and evaluation (GRADE) criteria. Consensus was reached for all statements. These guidelines suggest a positive diagnostic strategy within a symptom-based approach, comprehensive of psychological comorbidities assessment, alarm signs and symptoms' exclusion, testing for celiac disease and, under specific circumstances, fecal calprotectin and C-reactive protein. Consensus also suggests to rule out constipation in case of therapeutic failure. Conversely, routine stool testing for enteric pathogens, testing for food allergy/intolerance or small intestinal bacterial overgrowth are not recommended. Colonoscopy is recommended only in patients with alarm features. Regarding treatment, the consensus strongly suggests a dietary approach, psychologically directed therapies and, in specific conditions, gut-brain neuromodulators, under specialist supervision. Conditional recommendation was provided for both probiotics and specific fibers supplementation. Polyethylene glycol achieved consensus recommendation for specific subtypes of IBS. Secretagogues and 5-HT4 agonists are not recommended in children with IBS-C. Certain complementary alternative therapies, antispasmodics and, in specific IBS subtypes, loperamide and rifaximin could be considered.

Indexed as

GastroenterologyIrritable Bowel SyndromeAdolescentChildConsensusEndoscopy, GastrointestinalHumansItalyChildrenChronic abdominal painConstipationDiarrheaFunctional gastrointestinal disordersIrritable bowel syndrome

Identifiers

PMID38486305
PMCPMC10938778
OpenAlexW4392809091

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.