Evidence map›Paper›PMID 38487014›Full record

ArticleiScience2024

Glioblastoma stem cell-derived exosomal miR-374b-3p promotes tumor angiogenesis and progression through inducing M2 macrophages polarization.

Shilu Huang, Peng Zhang, Nanheng Yin, Zhipeng Xu, Xinglei Liu, Anyi Wu, Xiaopei Zhang, Zengyang Li, Zhicheng Zhang, Tao Zhong and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Shilu HuangDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Peng ZhangDepartment of Neurosurgery, Rugao People's Hospital, RuGao 226500, China.
Nanheng YinDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Zhipeng XuDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Xinglei LiuDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Anyi WuDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Xiaopei ZhangDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Zengyang LiDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Zhicheng ZhangDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Tao ZhongDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Liang LiuDepartment of Neurosurgery, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.
Yan ShiDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Jun DongDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Second Affiliated Hospital of Soochow University · CNSoochow University · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma stem cells (GSCs) reside in hypoxic periarteriolar niches of glioblastoma micro-environment, however, the crosstalk of GSCs with macrophages on regulating tumor angiogenesis and progression are not fully elucidated. GSCs-derived exosomes (GSCs-exos) are essential mediators during tumor immune-microenvironment remodeling initiated by GSCs, resulting in M2 polarization of tumor-associated macrophages (TAMs) as we reported previously. Our data disclosed aberrant upregulation of miR-374b-3p in both clinical glioblastoma specimens and human cell lines of GSCs. MiR-374b-3p level was high in GSCs-exos and can be internalized by macrophages. Mechanistically, GSCs exosomal miR-374b-3p induced M2 polarization of macrophages by downregulating phosphatase and tensin expression, thereby promoting migration and tube formation of vascular endothelial cells after coculture with M2 macrophages. Cumulatively, these data indicated that GSCs exosomal miR-374b-3p can enhance tumor angiogenesis by inducing M2 polarization of macrophages, as well as promote malignant progression of glioblastoma. Targeting exosomal miR-374b-3p may serve as a potential target against glioblastoma.

Indexed as

CancerImmunologyMolecular biology

Identifiers

PMID38487014
PMCPMC10937837
OpenAlexW4392028899

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.