Evidence map›Paper›PMID 38487248›Full record

ArticleChemical science2024

Molecular engineering of AIE-active boron clustoluminogens for enhanced boron neutron capture therapy.

Wenli Ma, Yanyang Wang, Yilin Xue, Mengmeng Wang, Changsheng Lu, Wanhua Guo, Yuan-Hao Liu, Diyun Shu, Guoqiang Shao, Qinfeng Xu and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
21.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Wenli MaState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University Nanjing 210023 China hyan1965@nju.edu.cn.
Yanyang WangDepartment of Nuclear Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University Nanjing 210008 China.
Yilin XueDepartment of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University Nanjing 210033 China.
Mengmeng WangState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University Nanjing 210023 China hyan1965@nju.edu.cn.
Changsheng LuState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University Nanjing 210023 China hyan1965@nju.edu.cn.ORCID https://orcid.org/0000-0002-6063-7754
Wanhua GuoDepartment of Nuclear Medicine, Nanjing Tongren Hospital, the Affiliated Hospital of Southeast University Medical School Nanjing 210033 China.
Yuan-Hao LiuNeuboron Therapy System Ltd. Xiamen 361028 China.
Diyun ShuNeuboron Therapy System Ltd. Xiamen 361028 China.
Guoqiang ShaoDepartment of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University Nanjing 210033 China.ORCID https://orcid.org/0000-0002-3277-6933
Qinfeng XuDepartment of Nuclear Medicine, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing 210029 China.
Deshuang TuState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University Nanjing 210023 China hyan1965@nju.edu.cn.
Hong YanState Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University Nanjing 210023 China hyan1965@nju.edu.cn.ORCID https://orcid.org/0000-0003-3993-0013
Nanjing University · CNNanjing Medical University · CNNeuboron (China) · CNNanjing Drum Tower Hospital · CNNanjing University of Chinese Medicine · CNTongren Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of boron delivery agents bearing an imaging capability is crucial for boron neutron capture therapy (BNCT), yet it has been rarely explored. Here we present a new type of boron delivery agent that integrates aggregation-induced emission (AIE)-active imaging and a carborane cluster for the first time. In doing so, the new boron delivery agents have been rationally designed by incorporating a high boron content unit of a carborane cluster, an erlotinib targeting unit towards lung cancer cells, and a donor-acceptor type AIE unit bearing naphthalimide. The new boron delivery agents demonstrate both excellent AIE properties for imaging purposes and highly selective accumulation in tumors. For example, at a boron delivery agent dose of 15 mg kg

Identifiers

PMID38487248
PMCPMC10935674
OpenAlexW4391453163

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.