ReviewThe Journal of clinical investigation2024
Lymphatic malformations: mechanistic insights and evolving therapeutic frontiers.
Review in The Journal of clinical investigation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Dual Clinical Presentation of a Birthmark: A Quiz.Acta dermato-venereologica · 2026Article
- A single-center retrospective study of a decade-long experience in managing pediatric lymphatic malformation.BMC pediatrics · 2026Article
- In Utero Molecular-Targeted Drug Therapies: Translational Principles, Pharmacologic Considerations, and Emerging Clinical Applications.Journal of clinical medicine · 2026Review
- Study on the Application of Indocyanine Green Lymphography in the Management of Microcystic Lymphatic Malformation: A Randomized Clinical Trial.Children (Basel, Switzerland) · 2026Article
- Analysis of the Occurrence ofChildren (Basel, Switzerland) · 2025Article
- Pilot Study: Endoscopic-assisted Plasma Radiofrequency Ablation: A Minimally Invasive Strategy for Extremity Lymphatic Malformations.Plastic and reconstructive surgery. Global open · 2025Article
- CT and MRI Key Features of Benign Tumors and Tumor-like Lesions of the Tongue: A Pictorial Review.Cancers · 2025Review
- Review
- Molecules That Have Rarely Been Studied in Lymphatic Endothelial Cells.International journal of molecular sciences · 2024Review
- Review
- Case report: A rare case of multifocal, combined lymphatic-venous malformation.Frontiers in medicine · 2024Article
- Targeting lymphatic function in cardiovascular-kidney-metabolic syndrome: preclinical methods to analyze lymphatic function and therapeutic opportunities.Frontiers in cardiovascular medicine · 2024Review
- Long-Term Remission of Peritoneal Lymphangiomatosis with Sirolimus Therapy: A Case Report with 8-Year Follow-Up.Case reports in gastroenterologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lymphatic vascular system is gaining recognition for its multifaceted role and broad pathological significance. Once perceived as a mere conduit for interstitial fluid and immune cell transport, recent research has unveiled its active involvement in critical physiological processes and common diseases, including inflammation, autoimmune diseases, and atherosclerosis. Consequently, abnormal development or functionality of lymphatic vessels can result in serious health complications. Here, we discuss lymphatic malformations (LMs), which are localized lesions that manifest as fluid-filled cysts or extensive infiltrative lymphatic vessel overgrowth, often associated with debilitating, even life-threatening, consequences. Genetic causes of LMs have been uncovered, and several promising drug-based therapies are currently under investigation and will be discussed.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.