Evidence map›Paper›PMID 38488472›Full record

ArticleAddiction biology2024

Paternal preconception alcohol consumption increased Angiotensin II-mediated vasoconstriction in male offspring cerebral arteries via oxidative stress-AT1R pathway.

Ze Zhang, Yumeng Zhang, Mingxing Liu, Hongyu Su, Yun He, Qiutong Zheng, Zhice Xu, Jiaqi Tang

Open access · goldAbstract read
In one paragraph

Article in Addiction biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ze ZhangInstitute for Fetology, First Hospital of Soochow University, Suzhou, China.
Yumeng ZhangInstitute for Fetology, First Hospital of Soochow University, Suzhou, China.
Mingxing LiuInfection Management Department, First Hospital of Soochow University, Suzhou, China.
Hongyu SuInstitute for Fetology, First Hospital of Soochow University, Suzhou, China.
Yun HeTaixing People's Hospital, Taixing, China.
Qiutong ZhengInstitute for Fetology, First Hospital of Soochow University, Suzhou, China.
Zhice XuInstitute for Fetology, First Hospital of Soochow University, Suzhou, China.
Jiaqi TangInstitute for Fetology, First Hospital of Soochow University, Suzhou, China.ORCID 0000-0002-3144-0194
Soochow University · CNTaixing People's Hospital · CN

Funding

National Key Research and Development Project of China 2019YFA0802601National Natural Science Foundation of China 82101761Natural Science Foundation of Jiangsu Province BK20200194Suzhou Natural Science Foundation KJXW2019006Suzhou Natural Science Foundation SYS2019042Taihu Rencai Project
6 · The paper itself

Abstract

Alcohol consumption is popular worldwidely and closely associated with cardiovascular diseases. Influences of paternal preconception alcohol consumption on offspring cerebral arteries are largely unknown. Male rats were randomly given alcohol or water before being mated with alcohol-naive females to produce alcohol- and control-sired offspring. Middle cerebral artery (MCA) was tested with a Danish Myo Technology wire myograph, patch-clamp, IONOPTIX, immunofluorescence and quantitative PCR. Alcohol consumption enhanced angiotensin II (AngII)-mediated constriction in male offspring MCA mainly via AT1R. PD123,319 only augmented AngII-induced constriction in control offspring. AngII and Bay K8644 induced stronger intracellular calcium transient in vascular smooth muscle cells (VSMCs) from MCA of alcohol offspring. L-type voltage-dependent calcium channel (L-Ca

Indexed as

Angiotensin IIVasoconstrictionAlcohol DrinkingAnimalsCalciumCerebral ArteriesFemaleMaleOxidative StressRatsAngiotensin IICalciumangiotensin IIcerebral arteriesintracellular calciumion channelmitochondriaoxidative stresspaternal preconception alcohol consumption

Identifiers

PMID38488472
PMCPMC11061854
OpenAlexW4392888381

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.