Evidence map›Paper›PMID 38488773›Full record

SynthesisJournal of clinical hypertension (Greenwich, Conn.)2024

Adherence to antihypertensives in the United States: A comparative meta-analysis of 23 million patients.

Yomna E Dean, Karam R Motawea, Mohamed A Shebl, Sameh Samir Elawady, Kaamel Nuhu, Basel Abuzuaiter, Karen Awayda, Ahmed Mahmoud Fouad, Yousef Tanas, Raquel Batista and 14 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of clinical hypertension (Greenwich, Conn.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Yomna E DeanFaculty of Medicine, Alexandria University, Alexandria, Egypt.ORCID 0000-0001-6907-0339
Karam R MotaweaFaculty of Medicine, Alexandria University, Alexandria, Egypt.
Mohamed A SheblFaculty of Medicine, Cairo University, Kasr Al-Ainy, Cairo, Egypt.ORCID 0009-0009-4657-0272
Sameh Samir ElawadyMedical University of South Carolina, Charleston, USA.
Kaamel NuhuSUNY Upstate Medical University, Syracuse, USA.
Basel AbuzuaiterSUNY Upstate Medical University, Syracuse, USA.
Karen AwaydaSUNY Upstate Medical University, Syracuse, USA.
Ahmed Mahmoud FouadFaculty of Medicine, Suez Canal University, Ismailia, Egypt.
Yousef TanasFaculty of Medicine, Alexandria University, Alexandria, Egypt.
Raquel BatistaSUNY Upstate Medical University, Syracuse, USA.
Ahmed ElsayedFaculty of Medicine, Suez Canal University, Ismailia, Egypt.
Noheir A I F HassanFaculty of Medicine, Aswan University, Aswan, Egypt.
Amro A El-SakkaFaculty of Medicine, Suez Canal University, Ismailia, Egypt.
Walaa HasanFaculty of Medicine, Suez Canal University, Ismailia, Egypt.
Raabia HusainSUNY Buffalo, Buffalo, USA.
Amanda LoisMedical University of South Carolina, Charleston, USA.
Aryan AroraSyracuse University, Syracuse, USA.
Abhinav AroraSyracuse University, Syracuse, USA.
Elyas AyadSUNY Oswego, Oswego, USA.
Mohamed A ElbahaieIbn Sina National College for Medical Studies, Jeddah, Saudi Arabia.
Jaffer ShahWeill Cornell Medicine, New York, USA.ORCID 0000-0002-8961-218X
Amr ShadySUNY Upstate Medical University, Syracuse, USA.
Debanik ChaudhuriSUNY Upstate Medical University, Syracuse, USA.
Hani AiashSUNY Upstate Medical University, Syracuse, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adherence to antihypertensives is crucial for control of blood pressure. This study analyzed factors and interventions that could affect adherence to antihypertensives in the US. PubMed, Scopus, Web of Science, and Embase were searched on January 21, 2022 and December 25, 2023 for studies on the adherence to antihypertensives in the US. Nineteen studies and 23 545 747 patients were included in the analysis, which showed that adherence to antihypertensives was the highest among Whites (OR: 1.47, 95% CI 1.34-1.61 compared to African Americans). Employment status and sex were associated with insignificant differences in adherence rates. In contrast, marital status yielded a significant difference where unmarried patients demonstrated low adherence rates compared to married ones (OR: 0.8, 95% CI 0.67-0.95). On analysis of comorbidities, diabetic patients reported lower adherence to antihypertensives (OR: 0.95, 95% CI 0.92-0.97); furthermore, patients who did not have Alzheimer showed higher adherence rates. Different BMIs did not significantly affect the adherence rates. Patients without insurance reported significantly lower adherence rates than insured patients (OR: 3.93, 95% CI 3.43-4.51). Polypill users had higher adherence rates compared with the free-dose combination (OR: 1.21, 95% CI 1.2-1.21), while telepharmacy did not prove to be as effective. Lower adherence rates were seen among African Americans, uninsured, or younger patients. Accordingly, interventions such as fixed-dose combinations should be targeted at susceptible groups. Obesity and overweight did not affect the adherence to antihypertensives.

Indexed as

Antihypertensive AgentsHypertensionBlood PressureDiabetes MellitusFemaleHumansMaleMedication AdherenceUnited StatesAntihypertensive Agentsantihypertensive agentsmedication adherencepatient complianceUnited States

Identifiers

PMID38488773
PMCPMC11007819

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.