Evidence map›Paper›PMID 38488949›Full record

Trial reportGeroScience2024

The impact of exercise on blood-based biomarkers of Alzheimer's disease in cognitively unimpaired older adults.

Kelsey R Sewell, Stephanie R Rainey-Smith, Steve Pedrini, Jeremiah J Peiffer, Hamid R Sohrabi, Kevin Taddei, Shaun J Markovic, Ralph N Martins, Belinda M Brown

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in GeroScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Prospective study on physical activity and Alzheimer's disease-related biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  5. Article
  6. Physical activity, aerobic fitness, and AD blood biomarkers: The IGNITE study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  7. Article
  8. Review
  9. Objective physical activity and Alzheimer's disease burden in the population-based Rotterdam Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  10. Lifestyle factors and plasma biomarkers of Alzheimer's disease: A narrative review.The journal of prevention of Alzheimer's disease · 2025
    Review
  11. Article
  12. Blood biomarkers differentiate AD-related versus non-AD-related cognitive deficits.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  13. Review
  14. Review
  15. Exercise to Counteract Alzheimer's Disease: What Do Fluid Biomarkers Say?International journal of molecular sciences · 2024
    Review
  16. Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Kelsey R SewellCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA, Australia. Kelsey.sewell@murdoch.edu.au.ORCID 0000-0002-3859-5017
Stephanie R Rainey-SmithCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA, Australia.
Steve PedriniSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Jeremiah J PeifferCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA, Australia.
Hamid R SohrabiCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA, Australia.
Kevin TaddeiSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Shaun J MarkovicCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA, Australia.
Ralph N MartinsSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Belinda M BrownCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA, Australia.
Edith Cowan University · AUMurdoch University · AU

Funding

National Health and Medical Research Council GNT1097105
6 · The paper itself

Abstract

Physical activity is a promising preventative strategy for Alzheimer's disease: it is associated with lower dementia risk, better cognition, greater brain volume and lower brain beta-amyloid. Blood-based biomarkers have emerged as a low-cost, non-invasive strategy for detecting preclinical Alzheimer's disease, however, there is limited literature examining the effect of exercise (a structured form of physical activity) on blood-based biomarkers. The current study investigated the influence of a 6-month exercise intervention on levels of plasma beta-amyloid (Aβ42

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBiomarkersCognitionExerciseGlial Fibrillary Acidic ProteinNeurofilament Proteinstau ProteinsAgedExercise TherapyFemaleHumansMaleMiddle AgedAmyloid beta-PeptidesBiomarkersGFAP protein, humanGlial Fibrillary Acidic Proteinneurofilament protein LNeurofilament Proteinstau ProteinsAlzheimer’s diseaseBlood biomarkersCognitionExercise

Identifiers

PMID38488949
PMCPMC11493998
OpenAlexW4392847967

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.