Evidence map›Paper›PMID 38488990›Full record

ReviewCurrent oncology reports2024

Cerebrospinal Fluid Liquid Biopsies in the Evaluation of Adult Gliomas.

Allison R Valerius, Mason J Webb, Nouran Hammad, Ugur Sener, Rachna Malani

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current oncology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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  4. Leptomeningeal Disease: Current Approaches and Future Directions.Current neurology and neuroscience reports · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Allison R ValeriusDepartment of Neurology, Mayo Clinic, Rochester, MN, USA. Valerius.Allison@Mayo.edu.ORCID 0000-0002-1708-6205
Mason J WebbDepartment of Medical Oncology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-4775-9164
Nouran HammadJordan University of Science and Technology School of Medicine, Irbid, Jordan.ORCID 0000-0002-5468-7472
Ugur SenerDepartment of Neurology, Department of Medical Oncology, Mayo Clinic, Rochester, MN, USA.
Rachna MalaniUniversity of UT - Huntsman Cancer Institute (Department of Neurosurgery), Salt Lake City, UT, USA.
Mayo Clinic in Arizona · USHuntsman Cancer Institute · USJordan University of Science and Technology · JOMayo Clinic · US

Funding

Mayo Clinic Center for Clinical and Translational Science (CCaTS UL1 Supplement - Dr. Timothy Curry)UL1TR002377 · NCATS · MAYO CLINIC ROCHESTER · PI VESNA D GAROVIC · 2017 to 2026
$78.4M
NCATS NIH HHS UL1 TR002377
6 · The paper itself

Abstract

purpose of reviewThis review aims to discuss recent research regarding the biomolecules explored in liquid biopsies and their potential clinical uses for adult-type diffuse gliomas. RECENT

findingsEvaluation of tumor biomolecules via cerebrospinal fluid (CSF) is an emerging technology in neuro-oncology. Studies to date have already identified various circulating tumor DNA, extracellular vesicle, micro-messenger RNA and protein biomarkers of interest. These biomarkers show potential to assist in multiple avenues of central nervous system (CNS) tumor evaluation, including tumor differentiation and diagnosis, treatment selection, response assessment, detection of tumor progression, and prognosis. In addition, CSF liquid biopsies have the potential to better characterize tumor heterogeneity compared to conventional tissue collection and CNS imaging. Current imaging modalities are not sufficient to establish a definitive glioma diagnosis and repeated tissue sampling via conventional biopsy is risky, therefore, there is a great need to improve non-invasive and minimally invasive sampling methods. CSF liquid biopsies represent a promising, minimally invasive adjunct to current approaches which can provide diagnostic and prognostic information as well as aid in response assessment.

Indexed as

Central Nervous System NeoplasmsCirculating Tumor DNAGliomaMicroRNAsAdultBiomarkers, TumorHumansLiquid BiopsyBiomarkers, TumorCirculating Tumor DNAMicroRNAsCentral nervous system tumorsCerebrospinal fluid analysisctDNAExtracellular vesiclesGliomaLiquid biopsy

Identifiers

PMID38488990
OpenAlexW4392864221

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.