Evidence map›Paper›PMID 38489388›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

KCTD10 regulates brain development by destabilizing brain disorder-associated protein KCTD13.

Jianbo Cheng, Zhen Wang, Manpei Tang, Wen Zhang, Guozhong Li, Senwei Tan, Chenjun Mu, Mengyuan Hu, Dan Zhang, Xiangbin Jia and 10 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Aryl Hydrocarbon Receptor (AHR) Suppresses Arsenic (AsInternational journal of biological sciences · 2025
    Article
  5. Article
  6. Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Jianbo Cheng *Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Sciences, Central South University, Changsha, Hunan 410078, China.
Zhen Wang *Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Sciences, Central South University, Changsha, Hunan 410078, China.
Manpei Tang *Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Sciences, Central South University, Changsha, Hunan 410078, China.
Wen Zhang *Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Sciences, Central South University, Changsha, Hunan 410078, China.
Guozhong Li *Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Sciences, Central South University, Changsha, Hunan 410078, China.
Senwei TanCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Sciences, Central South University, Changsha, Hunan 410078, China.
Chenjun MuCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Sciences, Central South University, Changsha, Hunan 410078, China.
Mengyuan HuCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Sciences, Central South University, Changsha, Hunan 410078, China.
Dan ZhangState Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100101, China.
Xiangbin JiaCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Sciences, Central South University, Changsha, Hunan 410078, China.
Yangxuan WenCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Sciences, Central South University, Changsha, Hunan 410078, China.
Hui GuoCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Sciences, Central South University, Changsha, Hunan 410078, China.
Dan XuFujian Key Laboratory of Molecular Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou 350005, China.
Liang LiuDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.ORCID 0009-0005-0162-1241
Jiada LiCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Sciences, Central South University, Changsha, Hunan 410078, China.ORCID 0000-0002-4236-3518
Kun XiaCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Sciences, Central South University, Changsha, Hunan 410078, China.
Faxiang LiCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Sciences, Central South University, Changsha, Hunan 410078, China.
Ranhui DuanCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Sciences, Central South University, Changsha, Hunan 410078, China.
Zhiheng XuState Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100101, China.ORCID 0000-0002-4809-2851
Ling YuanCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Sciences, Central South University, Changsha, Hunan 410078, China.
Central South University · CNInstitute of Genetics and Developmental Biology · CNCapital Medical University · CNFujian Medical University · CN

Funding

CAS | Institute of Genetics and Developmental Biology, Chinese Academy of Sciences (IGDB) 2019-MDB-KF-19CAS | Institute of Genetics and Developmental Biology, Chinese Academy of Sciences (IGDB) 2020-MDB-KF-21CAS | Institute of Genetics and Developmental Biology, Chinese Academy of Sciences (IGDB) 2022-MDB-KF-24CSU | Innovation-Driven Project of Central South University 2020CX022HSTD | Natural Science Foundation of Hunan Province () 2020JJ4689HSTD | Natural Science Foundation of Hunan Province () 2021JJ20075Huxiang Youth Talent Support Program (Huxiang Young Talents) 2020RC3006Key Research and Development Program of Hunan Province of China () 2018DK201MOST | National Natural Science Foundation of China (NSFC) 32070980MOST | National Natural Science Foundation of China (NSFC) 32271026MOST | National Natural Science Foundation of China (NSFC) 81901168
6 · The paper itself

Abstract

KCTD10 belongs to the KCTD (potassiumchannel tetramerization domain) family, many members of which are associated with neuropsychiatric disorders. However, the biological function underlying the association with brain disorders remains to be explored. Here, we reveal that Kctd10 is highly expressed in neuronal progenitors and layer V neurons throughout brain development.

Indexed as

Brain DiseasesNeurodevelopmental DisordersPotassium Channels, Voltage-GatedAnimalsBrainMiceNeurogenesisNeuronsProteinsKCTD10 protein, mousePotassium Channels, Voltage-GatedProteinscortical neurogenesisKCTD10KCTD13motor deficitsubiquitination-dependent degradation

Identifiers

PMID38489388
PMCPMC10963008
OpenAlexW4392857134

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.