Evidence map›Paper›PMID 38490532›Full record

Trial reportThe Journal of nutrition2024

Effects of Prune (Dried Plum) Supplementation on Cardiometabolic Health in Postmenopausal Women: An Ancillary Analysis of a 12-Month Randomized Controlled Trial, The Prune Study.

Janhavi J Damani, Connie J Rogers, Hang Lee, Nicole Ca Strock, Kristen J Koltun, Nancy I Williams, Connie Weaver, Mario G Ferruzzi, Cindy H Nakatsu, Mary Jane De Souza

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02822378 (Randomized Control Trial of Dietary Supplementation With Dried Plums on Bone Density, Geometry and Estimated Bone Strength in Postmenopausal Women), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02822378 naactive not recruitingnot on this map

Randomized Control Trial of Dietary Supplementation With Dried Plums on Bone Density, Geometry and Estimated Bone Strength in Postmenopausal Women

TypeinterventionalSponsorPenn State UniversityRan2016 to 2027Enrolled322ConditionsPostmenopausal OsteoporosisArmsDried Plum, Calcium supplement, Vitamin D supplement
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Janhavi J DamaniThe Intercollege Graduate Degree Program in Integrative and Biomedical Physiology, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, United States; Department of Kinesiology, The Pennsylvania State University, University Park, PA, United States.
Connie J RogersDepartment of Nutritional Sciences, University of Georgia, Athens, GA, United States.
Hang LeeBiostatistics Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Nicole Ca StrockDepartment of Kinesiology, The Pennsylvania State University, University Park, PA, United States.
Kristen J KoltunDepartment of Kinesiology, The Pennsylvania State University, University Park, PA, United States; Department of Sports Medicine and Nutrition, University of Pittsburgh, Pittsburgh, PA, United States.
Nancy I WilliamsDepartment of Kinesiology, The Pennsylvania State University, University Park, PA, United States.
Connie WeaverSchool of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA, United States.
Mario G FerruzziArkansas Children's Nutrition Center, Department of Pediatrics, University of Arkansas for Medical Science, Little Rock, AR, United States.
Cindy H NakatsuDepartment of Agronomy, Purdue University, West Lafayette, IN, United States.
Mary Jane De SouzaDepartment of Kinesiology, The Pennsylvania State University, University Park, PA, United States. Electronic address: mjd34@psu.edu.
Pennsylvania State University · USArkansas Children's Nutrition Center · USHarvard University · USPurdue University West Lafayette · USSan Diego State University · USUniversity of Georgia · US

Funding

J: Penn State NRSA Training CoreTL1TR002016 · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · 2025 to 2025
$354k
NCATS NIH HHS TL1 TR002016
6 · The paper itself

Abstract

backgroundEstrogen withdrawal during menopause is associated with an unfavorable cardiometabolic profile. Prunes (dried plums) represent an emerging functional food and have been previously demonstrated to improve bone health. However, our understanding of the effects of daily prune intake on cardiometabolic risk factors in postmenopausal women is limited.

objectivesWe conducted an ancillary investigation of a randomized controlled trial (RCT), The Prune Study, to evaluate the effect of 12-mo prune supplementation on cardiometabolic health markers in postmenopausal women.

methodsThe Prune Study was a single-center, parallel-design, 12-mo RCT in which postmenopausal women were allocated to no-prune control, 50 g/d prune, or 100 g/d prune groups. Blood was collected at baseline, 6 mo, and 12 mo/post to measure markers of glycemic control and blood lipids. Body composition was assessed at baseline, 6 mo, and 12 mo/post using dual-energy X-ray absorptiometry. Linear mixed-effects models were used to evaluate the effect of time, treatment, and their interaction on cardiometabolic health markers, all quantified as exploratory outcomes.

resultsA total of 183 postmenopausal women (mean age, 62.1 ± 4.9 y) completed the entire 12-mo RCT: control (n = 70), 50 g/d prune (n = 67), and 100 g/d prune (n = 46). Prune supplementation at 50 g/d or 100 g/d did not alter markers of glycemic control and blood lipids after 12 mo compared with the control group (all P > 0.05). Furthermore, gynoid percent fat and visceral adipose tissue (VAT) indices did not significantly differ in women consuming 50 g/d or 100 g/d prunes compared with the control group after 12 mo of intervention. However, android total mass increased by 3.19% ± 5.5% from baseline in the control group, whereas the 100 g/d prune group experienced 0.02% ± 5.6% decrease in android total mass from baseline (P < 0.01).

conclusionsPrune supplementation at 50 g/d or 100 g/d for 12 mo does not improve glycemic control and may prevent adverse changes in central adiposity in postmenopausal women. This trial was registered at clinicaltrials.gov as NCT02822378.

Indexed as

Dietary SupplementsPostmenopauseAgedBiomarkersBlood GlucoseBody CompositionCardiometabolic Risk FactorsCardiovascular DiseasesFemaleHumansMiddle AgedPrunus domesticaBiomarkersBlood Glucosecardiometabolic risk factorsmenopausenutritional interventionprunesrandomized controlled trial

Identifiers

PMID38490532
PMCPMC11347804
OpenAlexW4392748213

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.