Evidence map›Paper›PMID 38492129›Full record

Trial reportBrain imaging and behavior2024

Lack of effects of eight-week left dorsolateral prefrontal theta burst stimulation on white matter macro/microstructure and connection in autism.

Chun-Hung Yeh, Po-Chun Lin, Rung-Yu Tseng, Yi-Ping Chao, Chen-Te Wu, Tai-Li Chou, Rou-Shayn Chen, Susan Shur-Fen Gau, Hsing-Chang Ni, Hsiang-Yuan Lin

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Brain imaging and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Chun-Hung YehDepartment of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan.ORCID http://orcid.org/0000-0001-5727-9346
Po-Chun LinDepartment of Psychiatry, Chang Gung Memorial Hospital at Linkou, No.5 Fusing St. Gueishan, Taoyuan, 333, Taiwan.
Rung-Yu TsengDepartment of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan.
Yi-Ping ChaoDeparment of Computer Science and Information Engineering, Chang Gung University, Taoyuan, Taiwan.
Chen-Te WuDepartment of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
Tai-Li ChouDepartment of Psychology, National Taiwan University, Taipei, Taiwan.
Rou-Shayn ChenDepartment of Neurology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
Susan Shur-Fen GauGraduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan.
Hsing-Chang NiDepartment of Psychiatry, Chang Gung Memorial Hospital at Linkou, No.5 Fusing St. Gueishan, Taoyuan, 333, Taiwan. alanni@cgmh.org.tw.ORCID http://orcid.org/0000-0002-7804-7891
Hsiang-Yuan LinAzrieli Adult Neurodevelopmental Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-9519-209X
Chang Gung University · TWChang Gung Memorial Hospital · TWNational Taiwan University · TWCentre for Addiction and Mental Health · CALinkou Chang Gung Memorial Hospital · TW

Funding

Ministry of Science and Technology, Taiwan 110-2628-B-182A-016Ministry of Science and Technology, Taiwan 112-2221-E-182-029
6 · The paper itself

Abstract

Whether brain stimulation could modulate brain structure in autism remains unknown. This study explored the impact of continuous theta burst stimulation (cTBS) over the left dorsolateral prefrontal cortex (DLPFC) on white matter macro/microstructure in intellectually able children and emerging adults with autism. Sixty autistic participants were randomized (30 active) and received active or sham cTBS for eight weeks twice per week, 16 total sessions using a double-blind (participant-, rater-, analyst-blinded) design. All participants received high-angular resolution diffusion MR imaging at baseline and week 8. Twenty-eight participants in the active group and twenty-seven in the sham group with good imaging quality entered the final analysis. With longitudinal fixel-based analysis and network-based statistics, we found no significant difference between the active and sham groups in changes of white matter macro/microstructure and connections following cTBS. In addition, we found no association between baseline white matter macro/microstructure and autistic symptom changes from baseline to week 8 in the active group. In conclusion, we did not find a significant impact of left DLPFC cTBS on white matter macro/microstructure and connections in children and emerging adults with autism. These findings need to be interpreted in the context that the current intellectually able cohort in a single university hospital site limits the generalizability. Future studies are required to investigate if higher stimulation intensities and/or doses, other personal factors, or rTMS parameters might confer significant brain structural changes visible on MRI in ASD.

Indexed as

Autistic DisorderDorsolateral Prefrontal CortexTranscranial Magnetic StimulationWhite MatterAdolescentAdultChildDiffusion Magnetic Resonance ImagingDouble-Blind MethodFemaleHumansMaleNeural PathwaysPrefrontal CortexYoung AdultAutismDiffusion MRIDorsolateral prefrontal cortexTheta burst stimulationWhite matter

Identifiers

PMID38492129
OpenAlexW4392879793

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.