Evidence map›Paper›PMID 38494663›Full record

ArticleAging cell2024

MicroRNA-7 deficiency ameliorates d-galactose-induced aging in mice by regulating senescence of Kupffer cells.

Ya Wang, Hui Qiu, Shipeng Chen, Dongmei Li, Xu Zhao, Mengmeng Guo, Nana Li, Chao Chen, Ming Qin, Ya Zhou and 3 more

Open access · goldAbstract read
In one paragraph

Article in Aging cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
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  6. Review
  7. An Update on Neuroaging on Earth and in Spaceflight.International journal of molecular sciences · 2025
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Ya WangDepartment of Immunology, Zunyi Medical University, Zunyi, Guizhou, China.
Hui QiuDepartment of Immunology, Zunyi Medical University, Zunyi, Guizhou, China.
Shipeng ChenDepartment of Immunology, Zunyi Medical University, Zunyi, Guizhou, China.
Dongmei LiDepartment of Immunology, Zunyi Medical University, Zunyi, Guizhou, China.
Xu ZhaoKey Laboratory of Gene Detection and Treatment of Guizhou Province, Zunyi, Guizhou, China.
Mengmeng GuoDepartment of Immunology, Zunyi Medical University, Zunyi, Guizhou, China.
Nana LiKey Laboratory of Gene Detection and Treatment of Guizhou Province, Zunyi, Guizhou, China.
Chao ChenDepartment of Immunology, Zunyi Medical University, Zunyi, Guizhou, China.
Ming QinDepartment of Immunology, Zunyi Medical University, Zunyi, Guizhou, China.
Ya ZhouDepartment of Medical Physics, Zunyi Medical University, Zunyi, Guizhou, China.
Daimin XiaoKweichow Moutai Hospital, Renhuai, Guizhou, China.
Juanjuan ZhaoDepartment of Immunology, Zunyi Medical University, Zunyi, Guizhou, China.ORCID 0000-0001-9253-8083
Lin XuDepartment of Immunology, Zunyi Medical University, Zunyi, Guizhou, China.
Zunyi Medical University · CNGuhua Hospital · CNGuizhou Provincial Education Department · CNGuizhou University · CN

Funding

"12345 Future Talent Training Plan" of Zunyi Medical University-Future science and technology Elite talent project ZYSE-2022-04Collaborative Innovation Center of Chinese Ministry of Education 2020-39Guizhou Province Science and Technology Planning Project QKPTRC-2019-052Kweichow Moutai Hospital Health Industry Project MTyk2024-12National Natural Science Foundation of China 32160178National Natural Science Foundation of China 82272812National Natural Science Foundation of China 82360018Program for Excellent Young Talents of Zunyi Medical University 15ZY-001Program for Science and Technology Joint Fund Project in Zunyi Science and Technology Bureau and Zunyi Medical University ZSKH-HZ-2022-414Project of Guizhou Provincial Department of Science and Technology QKHJC-2022-623Project of Guizhou Provincial Department of Science and Technology QKHZC-2020-4Y156Project of Guizhou Provincial Department of Science and Technology QKHZC-2024-127Science and technology Fund project of Guizhou Provincial Health Commission gzwkj2022-271Zunyi Medical University doctoral research start-up fund project
6 · The paper itself

Abstract

Aging is intricately linked to immune system dysfunction. Recent studies have highlighted the biological function of microRNA-7 (miR-7) as a novel regulator of immune cell function and related diseases. However, the potential role of miR-7 in aging remains unexplored. Here, we investigated the contribution of miR-7 to d-gal-induced aging in mice, focusing on its regulation of senescent Kupffer cells. Our findings revealed that miR-7 deficiency significantly ameliorated the aging process, characterized by enhanced CD4

Indexed as

AgingGalactoseKruppel-Like Factor 4Kupffer CellsMicroRNAsAnimalsCellular SenescenceInterleukin-1betaMaleMiceMice, Inbred C57BLGalactoseInterleukin-1betaKlf4 protein, mouseKruppel-Like Factor 4MicroRNAsMIRN7 microRNA, mouseagingIL‐1βKLF4microRNA‐7senescent Kupffer cells

Identifiers

PMID38494663
PMCPMC11166366
OpenAlexW4392922385

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.