Evidence map›Paper›PMID 38495201›Full record

ArticleHeliyon2024

Preliminary insight on diarylpentanoids as potential antimalarials: In silico, in vitro

Amirah Hani Ramli, Puspanjali Swain, Muhammad Syafiq Akmal Mohd Fahmi, Faridah Abas, Sze Wei Leong, Bimo Ario Tejo, Khozirah Shaari, Amatul Hamizah Ali, Hani Kartini Agustar, Rusdam Awang and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Amirah Hani RamliNatural Medicines and Product Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, 43400, Selangor, Malaysia.
Puspanjali SwainDepartment of Biology, Chungnam National University, Daejeon, 34134, South Korea.
Muhammad Syafiq Akmal Mohd FahmiNatural Medicines and Product Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, 43400, Selangor, Malaysia.
Faridah AbasNatural Medicines and Product Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, 43400, Selangor, Malaysia.
Sze Wei LeongDepartment of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Bimo Ario TejoDepartment of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.
Khozirah ShaariNatural Medicines and Product Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, 43400, Selangor, Malaysia.
Amatul Hamizah AliDepartment of Earth Sciences and Environment, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, 43600, Selangor, Malaysia.
Hani Kartini AgustarDepartment of Earth Sciences and Environment, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, 43600, Selangor, Malaysia.
Rusdam AwangUPM - MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.
Yee Ling NgDepartment of Parasitology, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Yee Ling LauDepartment of Parasitology, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Mohammad Aidiel Md RazaliSchool of Graduate Studies, Management & Science University, 40100, Shah Alam, Malaysia.
Siti Nurulhuda MastukiNatural Medicines and Product Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, 43400, Selangor, Malaysia.
Norazlan Mohmad MisnanHerbal Medicine Research Centre, Institute for Medical Research, National Institutes of Health, 40170, Shah Alam, Selangor Darul Ehsan, Malaysia.
Siti Munirah Mohd FaudziNatural Medicines and Product Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, 43400, Selangor, Malaysia.
Cheol-Hee KimDepartment of Biology, Chungnam National University, Daejeon, 34134, South Korea.
Universiti Putra Malaysia · MYUniversity of Malaya · MYChungnam National University · KRNational University of Malaysia · MYInstitute for Medical Research · MYManagement and Science University · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria remains a major public health problem worldwide, including in Southeast Asia. Chemotherapeutic agents such as chloroquine (CQ) are effective, but problems with drug resistance and toxicity have necessitated a continuous search for new effective antimalarial agents. Here we report on a virtual screening of ∼300 diarylpentanoids and derivatives, in search of potential

Indexed as

Antimalarial activityDiarylpentanoidsMolecular dockingPfLDH inhibitorsZebrafish

Identifiers

PMID38495201
PMCPMC10943399
OpenAlexW4392601771

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.