ArticlemedRxiv : the preprint server for health sciences2024
Large-scale genome-wide association study of 398,238 women unveils seven novel loci associated with high-grade serous epithelial ovarian cancer risk.
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169 authors at 20 institutions in 26 countries.
Daniel R BarnesCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID 0000-0002-3781-7570
Jonathan P TyrerCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID 0000-0003-3724-4757
Joe DennisCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID 0000-0003-4591-1214
Goska LeslieCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Manjeet K BollaCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Michael LushCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Amber M AeiltsDepartment of Internal Medicine, Division of Human Genetics, The Ohio State University, Columbus, OH, USA.
Kristiina AittomäkiDepartment of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Nadine AndrieuInserm U900, Paris, France.
Irene L AndrulisDepartment of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Hoda Anton-CulverDepartment of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA, USA.
Adalgeir ArasonDepartment of Pathology, Landspitali - the National University Hospital of Iceland, Reykjavik, Iceland.
Banu K ArunDepartment of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Judith BalmañaHereditary Cancer Genetics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
Elisa V BanderaCancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Rosa B BarkardottirDepartment of Pathology, Landspitali - the National University Hospital of Iceland, Reykjavik, Iceland.
Lieke P V BergerUniversity Medical Center Groningen, Department of Genetics, University of Groningen, Groningen, The Netherlands.
Amy Berrington de GonzalezClinical Cancer Epidemiology, Institute of Cancer Research, London, UK.
Pascaline BerthetDépartement de Biopathologie, Centre François Baclesse, Caen, France.
Katarzyna BiałkowskaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Line BjørgeDepartment of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
Amie M BlancoCancer Genetics and Prevention Program, University of California San Francisco, San Francisco, CA, USA.
Marinus J BlokDepartment of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.
Kristie A BobolisCity of Hope Clinical Cancer Genetics Community Research Network, Duarte, CA, USA.
Natalia V BogdanovaDepartment of Radiation Oncology, Hannover Medical School, Hannover, Germany.
James D BrentonCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.ORCID 0000-0002-5738-6683
Henriett ButzDepartment of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
Saundra S BuysDepartment of Medicine, Huntsman Cancer Institute, University of Utah Health, Salt Lake City, UT, USA.
Maria A CaligoSOD Genetica Molecolare, University Hospital, Pisa, Italy.
Ian CampbellCancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Carmen CastilloHereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona, Spain.
Kathleen B M ClaesCentre for Medical Genetics, Ghent University, Gent, Belgium.
GEMO Study Collaborators
EMBRACE Collaborators
Sarah V ColonnaDepartment of Internal Medicine, Huntsman Cancer Institute, University of Utah Health, Salt Lake City, UT, USA.
Linda S CookDepartment of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, CO, USA.
Mary B DalyDepartment of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, USA.
Agnieszka Dansonka-MieszkowskaDepartment of Pathology and Laboratory Medicine, Institute of Oncology and Maria Sklodowska-Curie Cancer Center, Warsaw, Poland.
Miguel de la HoyaMolecular Oncology Laboratory, CIBERONC, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain.
Anna deFazioCentre for Cancer Research, The Westmead Institute for Medical Research, Sydney, New South Wales, Australia.
Allison DePersiaCenter for Medical Genetics, NorthShore University HealthSystem, Evanston, IL, USA.
Yuan Chun DingDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Susan M DomchekBasser Center for BRCA, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
Thilo DörkGynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Zakaria EinbeigiDepartment of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Christoph EngelInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
D Gareth EvansGenomic Medicine, Division of Evolution and Genomic Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester Universities Foundation Trust, St. Mary's Hospital, Manchester, UK.
Lenka ForetovaDepartment of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Renée T FortnerDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Florentia FostiraMolecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece.
Maria Cristina FotiVeneto Institute of Oncology IOV-IRCSS, Italy.
Eitan FriedmanSackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.
Megan N FroneNational Cancer Institute, Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA.
Patricia A GanzSchools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Centre, UCLA, Los Angeles, CA, USA.
Aleksandra Gentry-MaharajMRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, University College London, London, UK.
Gord GlendonLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada.
Andrew K GodwinDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
Anna González-NeiraHuman Genotyping Unit-CeGen, Spanish National Cancer Research Centre, Madrid, Spain.
Mark H GreeneNational Cancer Institute, Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA.
Jacek GronwaldDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Aliana Guerrieri-GonzagaDivision of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Ute HamannMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Thomas V O HansenDepartment of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Holly R HarrisProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Jan HaukeCenter for Familial Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Florian HeitzDepartment of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany.
Frans B L HogervorstFamily Cancer Clinic, The Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.
Maartje J HooningDepartment of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Chad D HuffDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
David G HuntsmanBritish Columbia's Ovarian Cancer Research (OVCARE) Program, BC Cancer, Vancouver General Hospital, and University of British Columbia, Vancouver, BC, Canada.
Evgeny N ImyanitovDepartment of Tumor Growth Biology, N.N. Petrov Institute of Oncology, St. Petersburg, Russia.
kConFab Investigators
Louise IzattClinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Anna JakubowskaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Paul A JamesSir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.
Ramunas JanaviciusState Research Institute Centre for Innovative Medicine, Vilnius, Lithuania.
Esther M JohnDepartment of Epidemiology & Population Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.
Siddhartha KarCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-2314-1426
Beth Y KarlanDavid Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, CA, USA.
Catherine J KennedyCentre for Cancer Research, The Westmead Institute for Medical Research, Sydney, New South Wales, Australia.
Lambertus A L M KiemeneyRadboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Irene KonstantopoulouMolecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece.
Jolanta KupryjanczykDepartment of Pathology and Laboratory Medicine, Institute of Oncology and Maria Sklodowska-Curie Cancer Center, Warsaw, Poland.
Yael LaitmanThe Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel.
Ofer LavieTechnion-Israel Institute of Technology, Haifa, Israel.
Kate LawrensonDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Women's Cancer Program at the Samuel Oschin Cancer Institute Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Jenny LesterDavid Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, CA, USA.
Fabienne LesueurInserm U900, Paris, France.
Carlos Lopez-PleguezuelosFundación Pública Galega de Medicina Xenómica, Santiago de Compostela, Spain.
Phuong L MaiMagee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Siranoush ManoukianUnit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Taymaa MayPrincess Margaret Cancer Center, Toronto, Canada.
Iain A McNeishDivision of Cancer and Ovarian Cancer Action Research Centre, Department Surgery & Cancer, Imperial College London, London, UK.ORCID 0000-0002-9387-7586
Usha MenonMRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, University College London, London, UK.
Roger L MilneCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Francesmary ModugnoWomens Cancer Research Center, Magee-Womens Research Institute and Hillman Cancer Center, Pittsburgh, PA, USA.
Jennifer M MongioviDepartment of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA, USA.
Marco MontagnaImmunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
Kirsten B MoysichRoswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Susan L NeuhausenDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Finn C NielsenCenter for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Catherine NoguèsDépartement d'Anticipation et de Suivi des Cancers, Oncogénétique Clinique, Institut Paoli-Calmettes, Marseille, France.
Edit OláhDepartment of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
Olufunmilayo I OlopadeCenter for Clinical Cancer Genetics, The University of Chicago, Chicago, IL, USA.
Ana OsorioSpanish Network on Rare Diseases, Madrid, Spain.
Laura PapiDepartment of Experimental and Clinical Biomedical Sciences 'Mario Serio', Medical Genetics Unit, University of Florence, Florence, Italy.
Harsh PathakDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
Celeste L PearceDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Inge S PedersenMolecular Diagnostics, Aalborg University Hospital, Aalborg, Denmark.
Ana PeixotoDepartment of Laboratory Genetics, Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal.
Tanja PejovicDepartment of Obstetrics & Gynecology, Providence Medical Center, Medford, OR, USA.
Pei-Chen PengDepartment of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0002-5004-4322
Beth N PeshkinLombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Paolo PeterlongoGenome Diagnostics Program, IFOM - the FIRC Institute of Molecular Oncology, Milan, Italy.
C Bethan PowellHereditary Cancer Program, Kaiser Permanente Northern California, San Francisco, CA, USA.
Darya ProkofyevaUfa University of Science and Technology, Ufa, Russia.
Miquel Angel PujanaProCURE, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona, Spain.
Paolo RadiceUnit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
Muhammad U RashidMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Gad RennertTechnion-Israel Institute of Technology, Haifa, Israel.
George RichenbergMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Dale P SandlerEpidemiology Branch, National Institute of Environmental Health Sciences, NIH, Rockville, MD, USA.
Naoko SasamotoDepartment of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA, USA.
Veronica W SetiawanDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Priyanka SharmaDepartment of Internal Medicine, Division of Medical Oncology, University of Kansas Medical Center, Westwood, KS, USA.
Weiva SiehDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Christian F SingerDept of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Katie SnapeMedical Genetics Unit, St George's, University of London, London, UK.
Anna P SokolenkoDepartment of Tumor Growth Biology, N.N. Petrov Institute of Oncology, St. Petersburg, Russia.
Penny SoucyGenomics Center, Centre Hospitalier Universitaire de Québec - Université Laval Research Center, Québec City, QC, Canada.
Melissa C SoutheyPrecision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
Dominique Stoppa-LyonnetGenetics Department, Institut Curie, Paris, France.
Rebecca SutphenHealth Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Christian SutterInstitute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.
Manuel R TeixeiraDepartment of Laboratory Genetics, Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal.
Kathryn L TerryDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Liv Cecilie V ThomsenDepartment of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
Marc TischkowitzProgram in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, QC, Canada.
Amanda E TolandDepartment of Internal Medicine, Division of Human Genetics, The Ohio State University, Columbus, OH, USA.
Toon Van GorpDivision of Gynecologic Oncology, University Hospital Leuven, Leuven, Belgium.
Ana VegaFundación Pública Galega de Medicina Xenómica, Santiago de Compostela, Spain.
Digna R Velez EdwardsDepartment of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.
Penelope M WebbPopulation Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Jeffrey N WeitzelClinical Cancer Genomics, City of Hope, Duarte, CA, USA.
Nicolas WentzensenDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Alice S WhittemoreDepartment of Epidemiology & Population Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.
Stacey J WinhamDepartment of Quantitative Health Sciences, Mayo Clinic College of Medicine, Rochester, MN, USA.
Anna H WuDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Siddhartha YadavDepartment of Oncology, Mayo Clinic, Rochester, MN, USA.
Yao YuDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Argyrios ZiogasDepartment of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA, USA.
Andrew BerchuckDepartment of Gynecologic Oncology, Duke University Hospital, Durham, NC, USA.
Fergus J CouchDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Ellen L GoodeDepartment of Quantitative Health Sciences, Mayo Clinic College of Medicine, Rochester, MN, USA.
Marc T GoodmanSamuel Oschin Comprehensive Cancer Institute, Cancer Prevention and Genetics Program, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Alvaro N MonteiroDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
Kenneth OffitClinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Susan J RamusSchool of Clinical Medicine, Faculty of Medicine and Health, University of NSW Sydney, Sydney, New South Wales, Australia.
Harvey A RischChronic Disease Epidemiology, Yale School of Medicine, New Haven, CT, USA.
Joellen M SchildkrautDepartment of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Mads ThomassenDepartment of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Jacques SimardGenomics Center, Centre Hospitalier Universitaire de Québec - Université Laval Research Center, Québec City, QC, Canada.
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Michelle R JonesCenter for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Georgia Chenevix-TrenchDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Simon A GaytherCenter for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Antonis C AntoniouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Paul D P PharoahDepartment of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Cedars-Sinai Medical Center · USUniversity of Cambridge · GBBrigham and Women's Hospital · USInserm · FRUniversity of Southern California · USThe University of Melbourne · AUThe University of Texas MD Anderson Cancer Center · USGerman Cancer Research Center · DEMayo Clinic · USNorwegian Institute of Public Health · NOThe University of Sydney · AUMedizinische Hochschule Hannover · DEMRC Clinical Trials Unit at UCL · GBQIMR Berghofer Medical Research Institute · AUBC Cancer Agency · CACity of Hope · USColorado School of Public Health · USCopenhagen University Hospital · DKFox Chase Cancer Center · USGeorgetown University · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MUNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3MNRG Oncology Network Group Operations Center - GY9 BIQSFP Reports/BudgetsU10CA180868 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI NORMAN WOLMARK · 2014 to 2026
$206.8MUSC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4MSWOG Network Group Operations Center of the NCTNU10CA180888 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PRIMO N. LARA · 2014 to 2026
$152.1MWomen's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Lila J. Rutten · 1985 to 2026
$151.3MStatistics CoreU10CA180822 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI James J. Dignam · 2014 to 2026
$146.4MGYNECOLOGIC ONCOLOGY GROUP HEADQUARTERSU10CA027469 · NCI · GYNECOLOGIC ONCOLOGY GROUP · PI DISAIA, PHILIP J. · 1985 to 2013
$132.6MTwo-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI CANDACE S JOHNSON · 1985 to 2026
$116.6MTRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Tracie Saunders · 1997 to 2026
$94.5MTRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, TAMIMI, RULLA M · 2000 to 2019
$77.8MCancer Research UK 23382Intramural NIH HHS Z01 ES044005Intramural NIH HHS Z01 ES049033NCATS NIH HHS UL1 TR000124NCI NIH HHS K05 CA154337NCI NIH HHS K07 CA080668NCI NIH HHS K07 CA095666NCI NIH HHS K22 CA138563NCI NIH HHS N01 CN025403NCI NIH HHS N01 PC067010NCI NIH HHS N02 CP011019NCI NIH HHS N02 CP065504NCI NIH HHS P01 CA017054NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA016056NCI NIH HHS P30 CA016520NCI NIH HHS P30 CA051008NCI NIH HHS P30 CA062203NCI NIH HHS P30 CA072720NCI NIH HHS P30 CA076292NCI NIH HHS P30 CA168524NCI NIH HHS P50 CA105009NCI NIH HHS P50 CA116201NCI NIH HHS P50 CA125183NCI NIH HHS P50 CA136393NCI NIH HHS P50 CA159981NCI NIH HHS R00 CA256519NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA054281NCI NIH HHS R01 CA054419NCI NIH HHS R01 CA058598NCI NIH HHS R01 CA058860NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA063678NCI NIH HHS R01 CA063682NCI NIH HHS R01 CA067262NCI NIH HHS R01 CA074850NCI NIH HHS R01 CA076016NCI NIH HHS R01 CA080742NCI NIH HHS R01 CA083918NCI NIH HHS R01 CA087538NCI NIH HHS R01 CA095023NCI NIH HHS R01 CA106414NCI NIH HHS R01 CA112523NCI NIH HHS R01 CA116167NCI NIH HHS R01 CA122443NCI NIH HHS R01 CA126841NCI NIH HHS R01 CA128978NCI NIH HHS R01 CA140323NCI NIH HHS R01 CA142081NCI NIH HHS R01 CA142996NCI NIH HHS R01 CA149429NCI NIH HHS R01 CA160669NCI NIH HHS R01 CA176785NCI NIH HHS R01 CA192393NCI NIH HHS R01 CA214545NCI NIH HHS R01 CA248288NCI NIH HHS R01 CA260132NCI NIH HHS R03 CA113148NCI NIH HHS R03 CA115195NCI NIH HHS R03 CA130065NCI NIH HHS R25 CA112486NCI NIH HHS R35 CA253187NCI NIH HHS R37 CA054281NCI NIH HHS R37 CA070867NCI NIH HHS RC4 CA153828NCI NIH HHS U01 CA058860NCI NIH HHS U01 CA063464NCI NIH HHS U01 CA069417NCI NIH HHS U01 CA116167NCI NIH HHS U01 CA161032NCI NIH HHS U01 CA164920NCI NIH HHS U01 CA164973NCI NIH HHS U10 CA027469NCI NIH HHS U10 CA037517NCI NIH HHS U10 CA180822NCI NIH HHS U10 CA180868NCI NIH HHS U10 CA180888NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148537NCI NIH HHS UM1 CA164973NCI NIH HHS UM1 CA176726NCI NIH HHS UM1 CA186107NCRR NIH HHS M01 RR000056NCRR NIH HHS S10 RR025141NIGMS NIH HHS P20 GM130423Wellcome Trust
Abstract
Background: Nineteen genomic regions have been associated with high-grade serous ovarian cancer (HGSOC). We used data from the Ovarian Cancer Association Consortium (OCAC), Consortium of Investigators of Modifiers of Methods: We analyzed >22 million variants for 398,238 women. Associations were assessed separately by consortium and meta-analysed. OCAC and CIMBA data were used to develop PGS which were trained on FinnGen data and validated in UKBB and BioBank Japan. Results: Eight novel variants were associated with HGSOC risk. An interesting discovery biologically was finding that Conclusions: This study represents the largest GWAS for HGSOC to date. The results highlight that improvements in imputation reference panels and increased sample sizes can identify HGSOC associated variants that previously went undetected, resulting in improved PGS. The use of updated PGS in cancer risk prediction algorithms will then improve personalized risk prediction for HGSOC.
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