Evidence map›Paper›PMID 38500281›Full record

ArticleCurrent aging science2024

Neuroinflammatory Response and Redox-regulation Activity of Hyperoside in Manganese-induced Neurotoxicity Model of Wistar Rats.

Olalekan Bukunmi Ogunro, Oluwaseun Ruth Olasehinde

Abstract read
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In one paragraph

Article in Current aging science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Therapeutic potential ofFrontiers in pharmacology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Olalekan Bukunmi OgunroDepartment of Biological Sciences, Reproductive & Endocrinology, Toxicology, and Bioinformatics Research Laboratory, KolaDaisi University, Ibadan, Nigeria.ORCID 0000-0003-0524-5958
Oluwaseun Ruth OlasehindeDepartment of Biochemistry, University of Ilorin, Ilorin, Nigeria.
University of Ilorin · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExcessive manganese exposure can lead to neurotoxicity with detrimental effects on the brain. Neuroinflammatory responses and redox regulation play pivotal roles in this process. Exploring the impact of hyperoside in a Wistar rat model offers insights into potential neuroprotective strategies against manganese-induced neurotoxicity.

objectiveThe study investigated the neuroprotective efficacy of hyperoside isolated from the ethanol leaf extract of

methodsControl animals in Group 1 had access to regular drinking water, while animals in groups 2-4 were exposed to MnCl

resultsHELEGL effectively mitigated MnCl

conclusionIn summary, HELEGL reversed the causative factors of neurodegenerative diseases induced by MnCl

Indexed as

BrainChloridesDisease Models, AnimalManganese CompoundsNeuroprotective AgentsOxidation-ReductionOxidative StressQuercetinRats, WistarAnimalsAnti-Inflammatory AgentsAntioxidantsBehavior, AnimalInflammation MediatorsMaleMemoryAnti-Inflammatory AgentsAntioxidantsChlorideshyperosideInflammation Mediatorsmanganese chlorideManganese CompoundsNeuroprotective AgentsPlant ExtractsQuercetinAlzheimer’s diseaseCognition disorderDementiasGongronema latifoliumneurodegenerative diseasesNeurotransmitter.

Identifiers

PMID38500281
OpenAlexW4392965950

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.