Evidence map›Paper›PMID 38500830›Full record

ArticleiScience2024

Inflammatory, metabolic, and sex-dependent gene-regulatory dynamics of microglia and macrophages in neonatal hippocampus after hypoxia-ischemia.

Elena Di Martino, Anoop Ambikan, Daniel Ramsköld, Takashi Umekawa, Sarantis Giatrellis, Davide Vacondio, Alejandro Lastra Romero, Marta Gómez Galán, Rickard Sandberg, Ulrika Ådén and 4 more

Open access · goldAbstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Pro-inflammatory microglia-targeted peptide therapy ameliorates neonatal hypoxic-ischemic encephalopathy in mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Elena Di MartinoDepartment of Women's and Children's Health, Karolinska Institutet, 17177 Stockholm, Sweden.
Anoop AmbikanThe Systems Virology Lab, Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, 14152 Huddinge, Sweden.
Daniel RamsköldDepartment of Cell and Molecular Biology, Karolinska Institutet, 17165 Stockholm, Sweden.
Takashi UmekawaDepartment of Women's and Children's Health, Karolinska Institutet, 17177 Stockholm, Sweden.
Sarantis GiatrellisDepartment of Cell and Molecular Biology, Karolinska Institutet, 17165 Stockholm, Sweden.
Davide VacondioDepartment of Women's and Children's Health, Karolinska Institutet, 17177 Stockholm, Sweden.
Alejandro Lastra RomeroDepartment of Women's and Children's Health, Karolinska Institutet, 17177 Stockholm, Sweden.
Marta Gómez GalánDepartment of Physiology and Pharmacology, Karolinska Institutet, 17165 Stockholm, Sweden.
Rickard SandbergDepartment of Cell and Molecular Biology, Karolinska Institutet, 17165 Stockholm, Sweden.
Ulrika ÅdénDepartment of Women's and Children's Health, Karolinska Institutet, 17177 Stockholm, Sweden.
Volker M LauschkeDepartment of Physiology and Pharmacology, Karolinska Institutet, 17165 Stockholm, Sweden.
Ujjwal NeogiThe Systems Virology Lab, Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, 14152 Huddinge, Sweden.
Klas BlomgrenDepartment of Women's and Children's Health, Karolinska Institutet, 17177 Stockholm, Sweden.
Julianna KeleDepartment of Physiology and Pharmacology, Karolinska Institutet, 17165 Stockholm, Sweden.
Karolinska Institutet · SELinköping University · SEKarolinska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonatal hypoxia-ischemia (HI) is a major cause of perinatal death and long-term disabilities worldwide. Post-ischemic neuroinflammation plays a pivotal role in HI pathophysiology. In the present study, we investigated the temporal dynamics of microglia (CX3CR1

Indexed as

ImmunologyMolecular biologyNeurosciencePhysiologyTranscriptomics

Identifiers

PMID38500830
PMCPMC10945260
OpenAlexW4392244873

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.