Evidence map›Paper›PMID 38501300›Full record

ArticleZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences2024

Association between baseline hemoglobin level and early neurological deterioration after intravenous thrombolysis in patients with acute ischemic stroke.

Tinghuan Wang, Wansi Zhong, Zhicai Chen, Ke Shen, Huiya Ye, Zhihui Yu, Jia Luo, Jun Ma, Min Lou

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04487340 (Computer-based Online Database of Acute Stroke Patients for Stroke Management Quality Evaluation), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04487340 recruitingnot on this map

Computer-based Online Database of Acute Stroke Patients for Stroke Management Quality Evaluation

Typeobservational_patient_registrySponsorSecond Affiliated Hospital, Zhejiang University, School of MedicineRan2016 to 2028Enrolled200,000ConditionsStroke, AcuteArmsEducation
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tinghuan WangDepartment of Neurology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. tinghuanwang@zju.edu.cn.
Wansi ZhongDepartment of Neurology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Zhicai ChenDepartment of Neurology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Ke ShenDepartment of Neurology, Shaoxing Hospital Affiliated to China Medical University, Shaoxing 312099, Zhejiang Province, China.
Huiya YeDepartment of Neurology, Shaoxing Hospital Affiliated to China Medical University, Shaoxing 312099, Zhejiang Province, China.
Zhihui YuDepartment of Neurology, Shaoxing Hospital Affiliated to China Medical University, Shaoxing 312099, Zhejiang Province, China.
Jia LuoDepartment of Neurology, Shaoxing Hospital Affiliated to China Medical University, Shaoxing 312099, Zhejiang Province, China.
Jun MaDepartment of Neurology, Shaoxing Hospital Affiliated to China Medical University, Shaoxing 312099, Zhejiang Province, China.
Min LouDepartment of Neurology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. lm99@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the association between baseline hemoglobin level and early neurologic deterioration (END) after intravenous thrombolysis in patients with acute ischemic stroke (AIS).

methodsData of AIS patients who received intravenous thrombolytic therapy at multiple hospitals across the country between January 2017 and July 2020 were collected from the online database Acute Stroke Patients for Stroke Management Quality Evaluation (CASE-Ⅱ, NCT04487340). Binary logistic regression analysis was used to study the factors affecting the occurrence of END after intravenous thrombolytic therapy, and the correlation between baseline hemoglobin level and END was investigated by limiting cubic spline curve analysis.

resultsA total of 8162 patients were included. Patients with END had lower baseline hemoglobin levels (136 and 140 g/L,

conclusionsThere is a correlation between baseline hemoglobin level and the risk of END in AIS patients after intravenous thrombolysis, especially in male patients, in whom both lower and higher hemoglobin level may increase the risk of END.

Indexed as

AnemiaHemoglobinsIschemic StrokeThrombolytic TherapyAdministration, IntravenousAgedBrain IschemiaFemaleFibrinolytic AgentsHumansLogistic ModelsMaleMiddle AgedFibrinolytic AgentsHemoglobinsAcute ischemic strokeAnemiaEarly neurologic deteriorationHemoglobinIntravenous thrombolysisRetrospetive study

Identifiers

PMID38501300
PMCPMC11057983

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.