Evidence map›Paper›PMID 38503504›Full record

ReviewCold Spring Harbor perspectives in biology2024

Regulators of Oligodendrocyte Differentiation.

Ben Emery, Teresa L Wood

Abstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
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  7. Article
  8. The mCells · 2025
    Review
  9. Article
  10. Article
  11. Beyond Traditional Use: The Scientific Evidence for the Role ofPharmaceuticals (Basel, Switzerland) · 2025
    Review
  12. Review
  13. Review
  14. The Many Lives of an Oligodendrocyte Precursor Cell.Annual review of neuroscience · 2025
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Oligodendrocytes: Myelination, Plasticity, and Axonal Support.Cold Spring Harbor perspectives in biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Ben EmeryJungers Center for Neurosciences Research, Department of Neurology, Oregon Health & Science University, Portland, Oregon 97239, USA.
Teresa L WoodDepartment of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers University, Newark, New Jersey 07103, USA terri.wood@rutgers.edu.
Center for Neurosciences · USRutgers, The State University of New Jersey · US

Funding

The role of mTOR signaling in oligodendrocyte differentiation and CNS myelinationR37NS082203 · NINDS · UNIVERSITY OF COLORADO DENVER · PI MACKLIN, WENDY B, WOOD, TERESA L · 2017 to 2023
$6.0M
Neuronal responses to chronic demyelinationR01NS120981 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EMERY, BEN · 2021 to 2025
$2.1M
NINDS NIH HHS R01 NS120981NINDS NIH HHS R37 NS082203
6 · The paper itself

Abstract

Myelination has evolved as a mechanism to ensure fast and efficient propagation of nerve impulses along axons. Within the central nervous system (CNS), myelination is carried out by highly specialized glial cells, oligodendrocytes. The formation of myelin is a prolonged aspect of CNS development that occurs well into adulthood in humans, continuing throughout life in response to injury or as a component of neuroplasticity. The timing of myelination is tightly tied to the generation of oligodendrocytes through the differentiation of their committed progenitors, oligodendrocyte precursor cells (OPCs), which reside throughout the developing and adult CNS. In this article, we summarize our current understanding of some of the signals and pathways that regulate the differentiation of OPCs, and thus the myelination of CNS axons.

Indexed as

Cell DifferentiationMyelin SheathOligodendrogliaAnimalsAxonsCentral Nervous SystemHumansSignal Transduction

Identifiers

PMID38503504
PMCPMC11146316
OpenAlexW4392939907

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.