Evidence map›Paper›PMID 38504158›Full record

ArticleBMC cancer2024

Pan-cancer analysis of NUP155 and validation of its role in breast cancer cell proliferation, migration, and apoptosis.

Zi-Qiong Wang, Zhi-Xuan Wu, Zong-Pan Wang, Jing-Xia Bao, Hao-Dong Wu, Di-Yan Xu, Hong-Feng Li, Yi-Yin Xu, Rong-Xing Wu, Xuan-Xuan Dai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Postexercise downregulation ofTranslational cancer research · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Zi-Qiong Wang *Quzhou People's Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, 100 Minjiang Avenue, Quzhou, Zhejiang, 324000, Zhejiang, China.
Zhi-Xuan Wu *Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Zong-Pan WangQuzhou People's Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, 100 Minjiang Avenue, Quzhou, Zhejiang, 324000, Zhejiang, China.
Jing-Xia BaoDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Hao-Dong WuDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Di-Yan XuDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Hong-Feng LiDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Yi-Yin XuQuzhou People's Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, 100 Minjiang Avenue, Quzhou, Zhejiang, 324000, Zhejiang, China.
Rong-Xing WuQuzhou People's Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, 100 Minjiang Avenue, Quzhou, Zhejiang, 324000, Zhejiang, China. qzwrx@163.com.
Xuan-Xuan DaiQuzhou People's Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, 100 Minjiang Avenue, Quzhou, Zhejiang, 324000, Zhejiang, China. dashidaixuanxuan@126.com.
First Affiliated Hospital of Wenzhou Medical University · CNWenzhou Medical University · CN

Funding

Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education) 2022E10022Young Talent Program qnyc108Zhejiang Medical Health Science and technology Program 2019RC204
6 · The paper itself

Abstract

NUP155 is reported to be correlated with tumor development. However, the role of NUP155 in tumor physiology and the tumor immune microenvironment (TIME) has not been previously examined. This study comprehensively investigated the expression, immunological function, and prognostic significance of NUP155 in different cancer types. Bioinformatics analysis revealed that NUP155 was upregulated in 26 types of cancer. Additionally, NUP155 upregulation was strongly correlated with advanced pathological or clinical stages and poor prognosis in several cancers. Furthermore, NUP155 was significantly and positively correlated with DNA methylation, tumor mutational burden, microsatellite instability, and stemness score in most cancers. Additionally, NUP155 was also found to be involved in TIME and closely associated with tumor infiltrating immune cells and immunoregulation-related genes. Functional enrichment analysis revealed a strong correlation between NUP155 and immunomodulatory pathways, especially antigen processing and presentation. The role of NUP155 in breast cancer has not been examined. This study, for the first time, demonstrated that NUP155 was upregulated in breast invasive carcinoma (BRCA) cells and revealed its oncogenic role in BRCA using molecular biology experiments. Thus, our study highlights the potential value of NUP155 as a biomarker in the assessment of prognostic prediction, tumor microenvironment and immunotherapeutic response in pan-cancer.

Indexed as

Breast NeoplasmsCarcinomaApoptosisBreastCell ProliferationFemaleHumansNuclear Pore Complex ProteinsPrognosisTumor MicroenvironmentNuclear Pore Complex ProteinsNUP155 protein, humanImmune checkpointsImmune infiltrationMolecular biology experimentsNUP155Pan-cancer analysisPrognosis

Identifiers

PMID38504158
PMCPMC10953186
OpenAlexW4392948821

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.