Evidence map›Paper›PMID 38504284›Full record

ArticleCardiovascular diabetology2024

CVOT Summit Report 2023: new cardiovascular, kidney, and metabolic outcomes.

Oliver Schnell, Katharine Barnard-Kelly, Tadej Battelino, Antonio Ceriello, Helena Elding Larsson, Beatriz Fernández-Fernández, Thomas Forst, Juan-Pablo Frias, James R Gavin, Francesco Giorgino and 33 more

Open access · goldAbstract readLetter
In one paragraph

Article in Cardiovascular diabetology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

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  9. Mitochondrial Dysfunction in HFpEF: Potential Interventions Through Exercise.Journal of cardiovascular translational research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors at 20 institutions in 19 countries.

Oliver SchnellForschergruppe Diabetes e. V, Helmholtz Center Munich, Ingolstaedter Landstraße 1, 85764, Neuherberg (Munich), Germany. oliver.schnell@lrz.uni-muenchen.de.
Katharine Barnard-KellySouthern Health NHS Foundation Trust, Southampton, United Kingdom.
Tadej BattelinoUniversity Medical Center, Ljubljana, Slovenia.
Antonio CerielloIRCCS MultiMedica, Milan, Italy.
Helena Elding LarssonDepartment of Pediatrics, Skåne University Hospital, Malmö/Lund, Sweden.
Beatriz Fernández-FernándezDivision of Nephrology and Hypertension, University Hospital Fundación Jiménez Díaz, Madrid, Spain.
Thomas ForstCRS Clinical Research Services Mannheim GmbH, Mannheim, Germany.
Juan-Pablo FriasBiomea Fusion, Redwood City, CA, United States of America.
James R GavinEmory University School of Medicine, Atlanta, GA, United States of America.
Francesco GiorginoDepartment of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, Bari, Italy.
Per-Henrik GroopDepartment of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Hiddo J L HeerspinkDepartment of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Stephan HerzigDivision Diabetic Complications, Institute for Diabetes and Cancer, Helmholtz Center Munich, Neuherberg, Germany.
Michael HummelForschergruppe Diabetes e. V, Helmholtz Center Munich, Ingolstaedter Landstraße 1, 85764, Neuherberg (Munich), Germany.
George HuntleyDiabetes Leadership Council, Indianapolis, IN, United States of America.
Mahmoud IbrahimCenter for Diabetes Education, EDC, Charlotte, NC, United States of America.
Baruch ItzhakClalit Health Services, Haifa, Israel.
Stephan JacobPractice for Prevention and Therapy and Cardio-Metabolic Institute, Villingen-Schwenningen, Germany.
Linong JiPeking University People's Hospital, Xicheng District, Beijing, China.
Mikhail KosiborodDepartment of Cardiovascular Disease, Saint Luke's Mid America Heart Institute, University of Missouri-Kansas City School of Medicine, Kansas City, MO, United States of America.
Nebosja LalicClinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade, Serbia.
Sofia MacieiraSciarc GmbH, Baierbrunn, Germany.
Rayaz A MalikWeill Cornell Medicine-Qatar, Qatar Foundation-Education City, Ar-Rayyan, Doha, Qatar.
Boris MankovskyShupyk National Healthcare University of Ukraine, Kyiv, Ukraine.
Nikolaus MarxClinic for Cardiology, Pneumology, Angiology and Internal Intensive Care Medicine (Medical Clinic I), RWTH Aachen University Hospital, Aachen, Germany.
Chantal MathieuDepartment of Endocrinology, Catholic University Leuven, Leuven, Belgium.
Timo D MüllerInstitute for Diabetes and Obesity, Helmholtz Munich, Munich, Germany.
Kausik RaySchool of Public Health, Imperial College London, London, United Kingdom.
Helena W RodbardEndocrine and Metabolic Consultants, Rockville, MD, United States of America.
Peter RossingSteno Diabetes Center Copenhagen, Herlev, Denmark.
Lars RydénDepartment of Medicine K2, Karolinska Institute, Stockholm, Sweden.
Petra-Maria Schumm-DraegerCenter Internal Medicine Fünf Höfe, Munich, Germany.
Peter SchwarzMedical Clinic III, University Hospital Carl Gustav Carus, Dresden, Germany.
Jan ŠkrhaThird Medical Department and Laboratory for Endocrinology and Metabolism, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Frank SnoekAmsterdam University Medical Centers, Amsterdam, The Netherlands.
Frank TackeDepartment of Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany.
Bruce TaylorDiabetes Patient Advocacy Coalition, Tampa, FL, United States of America.
Britta Tendal JeppesenFuture Evidence Foundation, Melbourne, Australia.
Solomon TesfayeSheffield Teaching Hospitals, Sheffield, United Kingdom.
Pinar TopseverDepartment of Family Medicine, Acıbadem Mehmet Ali Aydınlar University School of Medicine, Istanbul, Türkiye.
Tina VilsbøllSteno Diabetes Center Copenhagen, Herlev, Denmark.
Xuefeng YuDivision of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Eberhard StandlForschergruppe Diabetes e. V, Helmholtz Center Munich, Ingolstaedter Landstraße 1, 85764, Neuherberg (Munich), Germany.
Helmholtz Zentrum München · DEUniversity of Copenhagen · DKAmerican Diabetes Association · USAmsterdam University Medical Centers · NLCenter for Health, Exercise and Sport Sciences · RSCharité - Universitätsmedizin Berlin · DECharles University · CZClalit Health Services · ILClinical Research Services · DEEmory University · USFusion (United States) · USHospital Universitario Fundación Jiménez Díaz · ESImperial College London · GBKarolinska Institutet · SEKent Hastanesi · TRKU Leuven · BELudwig-Maximilians-Universität München · DELund University · SEMonash Medical Centre · AUMultiMedica · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 9th Cardiovascular Outcome Trial (CVOT) Summit: Congress on Cardiovascular, Kidney, and Metabolic Outcomes was held virtually on November 30-December 1, 2023. This reference congress served as a platform for in-depth discussions and exchange on recently completed outcomes trials including dapagliflozin (DAPA-MI), semaglutide (SELECT and STEP-HFpEF) and bempedoic acid (CLEAR Outcomes), and the advances they represent in reducing the risk of major adverse cardiovascular events (MACE), improving metabolic outcomes, and treating obesity-related heart failure with preserved ejection fraction (HFpEF). A broad audience of endocrinologists, diabetologists, cardiologists, nephrologists and primary care physicians participated in online discussions on guideline updates for the management of cardiovascular disease (CVD) in diabetes, heart failure (HF) and chronic kidney disease (CKD); advances in the management of type 1 diabetes (T1D) and its comorbidities; advances in the management of CKD with SGLT2 inhibitors and non-steroidal mineralocorticoid receptor antagonists (nsMRAs); and advances in the treatment of obesity with GLP-1 and dual GIP/GLP-1 receptor agonists. The association of diabetes and obesity with nonalcoholic steatohepatitis (NASH; metabolic dysfunction-associated steatohepatitis, MASH) and cancer and possible treatments for these complications were also explored. It is generally assumed that treatment of chronic diseases is equally effective for all patients. However, as discussed at the Summit, this assumption may not be true. Therefore, it is important to enroll patients from diverse racial and ethnic groups in clinical trials and to analyze patient-reported outcomes to assess treatment efficacy, and to develop innovative approaches to tailor medications to those who benefit most with minimal side effects. Other keys to a successful management of diabetes and comorbidities, including dementia, entail the use of continuous glucose monitoring (CGM) technology and the implementation of appropriate patient-physician communication strategies. The 10th Cardiovascular Outcome Trial Summit will be held virtually on December 5-6, 2024 ( http://www.cvot.org ).

Indexed as

Cardiovascular DiseasesDiabetes MellitusDiabetes Mellitus, Type 2Heart FailureRenal Insufficiency, ChronicBlood GlucoseBlood Glucose Self-MonitoringHumansKidneyObesityStroke VolumeBlood GlucoseCardiovascular diseaseCGMChronic kidney diseaseDiabetesFinerenoneGLP-1 RAGuidelinesHeart failureMASLDNAFLDObesitySGLT2 inhibitorTeplizumab

Identifiers

PMID38504284
PMCPMC10953147
OpenAlexW4392948776

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.