ArticleCombinatorial chemistry & high throughput screening2024
The Role of Emodin in the Treatment of Bladder Cancer Based on Network Pharmacology and Experimental Verification.
Article in Combinatorial chemistry & high throughput screening, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
background and purposeEmodin, a compound derived from rhubarb and various traditional Chinese medicines, exhibits a range of pharmacological actions, including antiinflammatory, antiviral, and anticancer properties. Nevertheless, its pharmacological impact on bladder cancer (BLCA) and the underlying mechanism are still unclear. This research aimed to analyze the pharmacological mechanisms of Emodin against BLCA using network pharmacology analysis and experimental verification.
methodsInitially, network pharmacology was employed to identify core targets and associated pathways affected by Emodin in bladder cancer. Subsequently, the expression of key targets in normal bladder tissues and BLCA tissues was assessed by searching the GEPIA and HPA databases. The binding energy between Emodin and key targets was predicted using molecular docking. Furthermore,
resultsOur analysis identified 148 common genes targeted by Emodin and BLCA, with the top ten target genes including
conclusionThis study integrates network pharmacology with
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