Evidence map›Paper›PMID 38509416›Full record

ArticleGeroScience2024

Modulation of neural gene networks by estradiol in old rhesus macaque females.

Rita Cervera-Juanes, Kip D Zimmerman, Larry Wilhelm, Dongqin Zhu, Jessica Bodie, Steven G Kohama, Henryk F Urbanski

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rita Cervera-Juanes *Department of Translational Neuroscience, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC, 27157, USA. rcervera@wakehealth.edu.ORCID 0000-0002-0001-3640
Kip D Zimmerman *Center for Precision Medicine, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Larry WilhelmDepartment of Translational Neuroscience, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Dongqin ZhuDepartment of Translational Neuroscience, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Jessica BodieDepartment of Translational Neuroscience, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Steven G KohamaDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, 97006, USA.
Henryk F UrbanskiDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, 97006, USA.
Wake Forest University · USOregon National Primate Research Center · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Research Education ComponentP30AG066518 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KEVIN M DUFF, Lisa C Silbert · 2020 to 2026
$28.6M
Age-Associated Modulation of Gene Expression in the CNSRF1AG062220 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI URBANSKI, HENRYK F · 2018 to 2018
$3.4M
NIA NIH HHS P30 AG066518NIA NIH HHS P51 OD011092NIA NIH HHS RF1 AG062220NIH HHS P51 OD011092
6 · The paper itself

Abstract

The postmenopausal decrease in circulating estradiol (E2) levels has been shown to contribute to several adverse physiological and psychiatric effects. To elucidate the molecular effects of E2 on the brain, we examined differential gene expression and DNA methylation (DNAm) patterns in the nonhuman primate brain following ovariectomy (Ov) and subsequent subcutaneous bioidentical E2 chronic treatment. We identified several dysregulated molecular networks, including MAPK signaling and dopaminergic synapse response, that are associated with ovariectomy and shared across two different brain areas, the occipital cortex (OC) and prefrontal cortex (PFC). The finding that hypomethylation (p = 1.6 × 10

Indexed as

DNA MethylationEstradiolMacaca mulattaOvariectomyAnimalsBrainEstrogensFemaleGene Regulatory NetworksPrefrontal CortexEstradiolEstrogensAgingDNA methylationEstradiolOccipital cortexPrefrontal cortexRNA-Seq

Identifiers

PMID38509416
PMCPMC11493911
OpenAlexW4392982454

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.