Evidence map›Paper›PMID 38510139›Full record

ArticleiScience2024

Engineered FSHD mutations results in D4Z4 heterochromatin disruption and feedforward DUX4 network activation.

Xiangduo Kong, Nam Viet Nguyen, Yumeng Li, Jasmine Shaaban Sakr, Kate Williams, Sheila Sharifi, Jonathan Chau, Altay Bayrakci, Seiya Mizuno, Satoru Takahashi and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Xiangduo KongDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Nam Viet NguyenDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Yumeng LiDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Jasmine Shaaban SakrDepartment of Development and Cell Biology, School of Biological Sciences, University of California, Irvine, Irvine, CA, USA.
Kate WilliamsDepartment of Development and Cell Biology, School of Biological Sciences, University of California, Irvine, Irvine, CA, USA.
Sheila SharifiDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Jonathan ChauDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Altay BayrakciDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Seiya MizunoLaboratory Animal Resource Center in Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Satoru TakahashiLaboratory Animal Resource Center in Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Tohru KiyonoExploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan.
Rabi TawilNeuromuscular Disease Unit, Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA.
Ali MortazaviDepartment of Development and Cell Biology, School of Biological Sciences, University of California, Irvine, Irvine, CA, USA.
Kyoko YokomoriDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA.
University of California, Irvine · USUniversity of Tsukuba · JPChiba Cancer Center · JPUniversity of Rochester Medical Center · US

Funding

The Pathogenesis of Facioscapulohumeral Muscular DystrophyP01NS069539 · NINDS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI TAPSCOTT, STEPHEN J · 2010 to 2019
$12.3M
Genetic and epigenetic mechanisms of FSHD pathogenesisR01AR071287 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Seyed Ali Mortazavi, Kyoko Yokomori · 2017 to 2026
$4.6M
NIAMS NIH HHS R01 AR071287NINDS NIH HHS P01 NS069539
6 · The paper itself

Abstract

Facioscapulohumeral dystrophy (FSHD) is linked to contraction of D4Z4 repeats on chromosome 4q with

Indexed as

Cell biologyGenomicsMolecular biologyMolecular mechanism of gene regulation

Identifiers

PMID38510139
PMCPMC10951985
OpenAlexW4392302665

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.