ArticleFrontiers in medicine2024
Association of intrinsic capacity with functional ability, sarcopenia and systemic inflammation in pre-frail older adults.
Article in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 18 citations in OpenAlex.
- Possible osteosarcopenia is associated with loss in intrinsic capacity and early cognitive deficits: a longitudinal study of older adults in Singapore.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Gan-Mai-Da-Zao-Tang attenuates age-induced skeletal muscle wasting and improves mitochondrial function in mice.Journal of traditional and complementary medicine · 2026Article
- Leveraging interpretable machine learning to identify sarcopenia in middle-aged and older adults with intrinsic capacity decline: an analysis of CHARLS data under AWGS 2025.BMC medical informatics and decision making · 2026Article
- Development and internal validation of a nomogram for identifying intrinsic capacity impairment among community-dwelling older adults in China: a cross-sectional study.BMC geriatrics · 2026Article
- Current status of intrinsic capacity and influencing factor analysis of rural disabled older adults in China: a cross-sectional study.BMC geriatrics · 2026Article
- Intrinsic capacity and resilience in hospitalized older adults: a gender-stratified analysis of the PRIFOR score.BMC geriatrics · 2026Article
- Optimal type and dose of exercise to improve cognitive function in healthy and pre-sarcopenic older adults: a bayesian network meta-analysis of randomized controlled trials.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026Review
- Article
- Intrinsic capacity as an indicator of the risk of depression and anxiety: a prospective cohort study based on the UK Biobank.Frontiers in psychology · 2026Article
- Sarcopenia in the Aging Process: Pathophysiological Mechanisms, Clinical Implications, and Emerging Therapeutic Approaches.International journal of molecular sciences · 2025Review
- Establishing Ultrasound Thresholds for Sarcopenia Diagnosis in Older Brazilian Adults.Muscles (Basel, Switzerland) · 2025Article
- Prevalence of intrinsic capacity impairment and associated factors among retired older people in Cameroon.BMC geriatrics · 2025Article
- Association between intrinsic capacity and sarcopenia in older adults with type 2 diabetes: A cross-sectional study.Aging clinical and experimental research · 2025Article
- Immunosenescence and the Geriatric Giants: Molecular Insights into Aging and Healthspan.Medical sciences (Basel, Switzerland) · 2025Review
- Implications of intrinsic capacity subtypes for post-PCI patients older than 45.Scientific reports · 2025Article
- Impact of Oral Health Interventions on Sarcopenia and Frailty in Older Adults: A Systematic Review.Journal of clinical medicine · 2025Review
- Latent class analysis of intrinsic capacity among rural older adults in China and its influencing factors.Frontiers in public health · 2025Article
- Frailty: a global health challenge in need of local action.BMJ global health · 2024Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Decline in intrinsic capacity (IC) has been shown to accelerate progression to disability. The study aims to explore association of IC composite score with functional ability, sarcopenia and systemic inflammation in pre-frail older adults. Methods: Cross-sectional study of pre-frail older adults ≥60 years old recruited from the community and primary care centers. Composite scores of four domains of IC were measured: locomotion, vitality, cognition and psychological. FRAIL scale was used to define pre-frailty. Muscle mass was measured using the bioelectrical impedance analysis. Systemic inflammation biomarkers [Interleukin-6 (IL-6), Interleukin-10 (IL-10), Tumor Necrosis Factor Alpha (TNF-α), and Growth differentiated factor 15 (GDF-15)] were measured. Participants in the lowest tertile (T1) exhibited greater decline in IC. Results: A total of 398 pre-frail older adults were recruited, mean age was 72.7 ± 5.8 years, 60.1% female, education level 7.8 years, and 85.2% were of Chinese ethnicity. A total of 75.1% had decline in locomotion, 40.5% in vitality, 53.2% in cognition and 41.7% in psychological domain. A total of 95% had decline in at least one domain. T1 was significantly associated with ADL impairment (aOR 3.36, 95% CI 1.78-6.32), IADL impairment (aOR 2.37, 95% CI 1.36-4.13), poor perceived health (aOR 0.96, 95% CI 0.95-0.98), fall (aOR 1.63, 95% CI 1.05-2.84), cognitive impairment (aOR 8.21, 95% CI 4.69-14.39), depression (aOR 101.82, 95% CI 33.62-308.37), and sarcopenia (aOR 2.40, 95% CI 1.60-5.45). T1 had significant associations with GDF-15, IL-10, and IL-10 to TNF-α ratio. Conclusion: Decline in IC composite score among pre-frail older adults was associated with functional limitation, sarcopenia, and systemic inflammation.
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