ArticleBrain, behavior, & immunity - health2024
Genetic evidence for the causal effects of C-reactive protein on self-reported habitual sleep duration.
Article in Brain, behavior, & immunity - health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Serum inflammatory markers and total antioxidant capacity in relation to sleep outcome in the elderly.BMC geriatrics · 2026Observational
- Longitudinal and concurrent C-reactive protein and diet associations with cognitive function in the population-based Tromsø study.Journal of Alzheimer's disease : JAD · 2025Article
- Relationship between sleep duration and hearing loss among adults aged 20-69: exploration of the U-shaped curve pattern.Frontiers in neuroscience · 2025Article
- Per-and polyfluoroalkyl substances and disrupted sleep: mediating roles of proteins.Environmental advances · 2024Article
- Re-Evaluating Recommended Optimal Sleep Duration: A Perspective on Sleep Literacy.Children (Basel, Switzerland) · 2024Review
- Elevated C-reactive protein and IL-6 signalling are not the only determinants of sleep quality and duration.Brain, behavior, & immunity - health · 2024Article
- Author reply - Letter to the Editor "elevated C-reactive protein and IL-6 signalling are not the only determinants of sleep quality and duration".Brain, behavior, & immunity - health · 2024Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Inflammatory responses to acute stimuli are proposed to regulate sleep, but the relationship between chronic inflammation and habitual sleep duration is elusive. Here, we study this relation using genetically predicted level of chronic inflammation, indexed by CRP and IL6 signaling, and self-reported sleep duration. By Mendelian randomization analysis, we show that elevated CRP level within <10 mg/L has a homeostatic effect that facilitates maintaining 7-8 h sleep duration per day - making short-sleepers sleep longer (p = 2.42 × 10
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.