Evidence map›Paper›PMID 38515392›Full record

ArticleObesity (Silver Spring, Md.)2024

Exposure to 4,4'-DDE in visceral adipose tissue and weight loss in adolescents from the Teen-LABS cohort.

Bruna Rubbo, Zhenjiang Li, Phum Tachachartvanich, Brittney O Baumert, Hongxu Wang, Shudi Pan, Sarah Rock, Justin R Ryder, Todd Jenkins, Stephanie Sisley and 12 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 10 institutions in 2 countries.

Bruna RubboDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Zhenjiang LiDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0002-4806-6231
Phum TachachartvanichDepartment of Environmental Toxicology, University of California, Davis, California, USA.
Brittney O BaumertDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Hongxu WangDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Shudi PanDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Sarah RockDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Justin R RyderDepartment of Surgery, Northwestern University Feinberg School of Medicine and Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Todd JenkinsDivision of Biostatistics & Epidemiology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Stephanie SisleyUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Xiangping LinDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Scott BartellDepartment of Environmental and Occupational Health and Department of Statistics, University of California, Irvine, California, USA.
Thomas H IngeDepartment of Surgery, Northwestern University Feinberg School of Medicine and Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.ORCID 0000-0001-7782-1112
Stavra XanthakosDivision of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Brooklynn McNeilIrving Institute for Clinical and Translational Research, Columbia University, New York, New York, USA.
Anna R RobuckDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Michele A La MerrillDepartment of Environmental Toxicology, University of California, Davis, California, USA.
Douglas I WalkerGangarosa Department of Environmental Health, Emory University, Atlanta, Georgia, USA.
David V ContiDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Rob McConnellDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Sandrah P EckelDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Lida ChatziDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
University of Southern California · USCincinnati Children's Hospital Medical Center · USIcahn School of Medicine at Mount Sinai · USNorthwestern University · USChildren's Nutrition Research Center at Baylor College of Medicine · USChulabhorn Research Institute · THColumbia University · USEmory University · USUniversity of California, Davis · USUniversity of California, Irvine · US

Funding

Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Research ProjectUM1DK072493 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI INGE, THOMAS HARRIS · 2011 to 2020
$10.5M
Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) renewalUM1DK095710 · NIDDK · UNIVERSITY OF CINCINNATI · PI JENKINS, TODD M, XIE, CHANGCHUN · 2011 to 2020
$9.4M
Effects of DDE exposure on adipose tissue function, weight loss and metabolic improvement after bariatric surgery: A new paradigm for study of lipophilic chemicalsR01ES030364 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHATZI, VAIA LIDA · 2020 to 2024
$3.2M
NIDDK NIH HHS UM1 DK072493NIDDK NIH HHS UM1DK072493NIDDK NIH HHS UM1 DK095710NIDDK NIH HHS UM1DK095710NIEHS NIH HHS R01 ES030364NIEHS NIH HHS R01ES030364
6 · The paper itself

Abstract

objectiveDichlorodiphenyldichloroethylene (DDE), an obesogen accumulating in adipose tissue, is released into circulation with weight loss, although its impact is underexplored among adolescents. We tested the association using an integrative translational approach of epidemiological analysis among adolescents with obesity and in vitro measures exploring the impact of DDE on adipogenesis via preadipocytes.

methodsWe included 63 participants from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) cohort. We assessed 4,4'-DDE in visceral adipose tissue at surgery and BMI and waist circumference at surgery and 0.5, 1, 3, and 5 years after. We conducted longitudinal analysis to estimate the interaction on weight loss between DDE and time since surgery. In vitro analysis quantified adipogenic differentiation in commercial human preadipocytes exposed to 4,4'-DDE via fluorescent staining and imaging.

resultsA dose-response relationship was observed, with the low-exposure group having a greater reduction in BMI during the first year compared to higher-exposure groups and showing smaller regains compared to higher-exposure groups after the first year. In vitro analysis of preadipocytes treated with 4,4'-DDE during adipogenic differentiation for 12 days showed a concentration-dependent increase in lipid accumulation.

conclusionsDDE could contribute to weight trajectory among adolescents undergoing bariatric surgery, potentially mediated via promoted adipogenesis in preadipocytes.

Indexed as

AdipogenesisBariatric SurgeryBody Mass IndexDichlorodiphenyl DichloroethyleneIntra-Abdominal FatWeight LossAdipocytesAdolescentCohort StudiesFemaleHumansLongitudinal StudiesMalePediatric ObesityWaist CircumferenceDichlorodiphenyl Dichloroethylene

Identifiers

PMID38515392
PMCPMC11039378
OpenAlexW4393095100

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.